The significance of the criteria for the depth and configuration of pancreatic necrosis in acute pancreatitis in the formation of complicated pseudocysts
https://doi.org/10.17238/2072-3180-2023-1-34-42
Abstract
Introduction. It is known that pseudocysts (PC) are a consequence of damage to the pancreatic duct in pancreatic necrosis.
The purpose of the study. To study the effect of the depth and configuration of pancreatic necrosis in acute pancreatitis on the dynamics of pancreatic pseudocysts in the long-term period.
Materials and methods. A retrospective analysis was carried out and the long-term results of treatment were studied in 29 patients with PC who underwent pancreonecrosis, in whom the depth and configuration of pancreatic necrosis were assessed on the basis of CT with bolus contrast.
Results. There were no PC complications in 9 patients, no signs of duct damage were noted during acute pancreatitis.In 16 out of 20 patients, PC complications (increasing collections, infection, hemorrhagic complications, rupture) occurred after deep necrosis of type 1 configuration, in 13 they were combined.With not deep necrosis of type 1 (1) and with 2 (3) type of configuration, only infection was noted.At the stage of PC complications, percutaneous drainage (total 12, in 3 after embolization), necrectomy from mini-access (2),endovascular interventions (total 6, 1 patient died), endoscopic cystogastroanastomosis (3) were performed.The result of the interventions in 10 patients was the forced formation of an external pancreatic fistula, which later required additional interventions.
Conclusion. Deep necrosis of the pancreas in type 1 configuration during acute pancreatitis are important criteria determining the likelihood of PC complications.
About the Authors
T. G. DyuzhevaRussian Federation
Dyuzheva Tatiana Gennadievna – Doct. of Sci (Med.), Professor
8, Trubetskaya str., Moscow, 119991
D. L. Mudryak
Russian Federation
Mudryak Daniil Leonidovich – postgraduate; A surgeon of Surgical Department
8, Trubetskaya str., Moscow, 119991
10 Lobnenskaya str., Moscow, 127411
I. A. Semenenko
Russian Federation
Semenenko Ivan Albertovich – Cand. Of Sci (Med.) Associate Professor
8, Trubetskaya str., Moscow, 119991
A. V. Shefer
Russian Federation
Shefer Alexander Valerievich – Doct. of Sci (Med.), Head of Surgical Department
10 Lobnenskaya str., Moscow, 127411
A. P. Stepanchenko
Russian Federation
Stepanchenko Andrey Petrovich – Cand. Of Sci (Med.), Head of the Radiology Department
4, Kolomenskiy proezd, Moscow, 115446
A. A. Sokolov
Russian Federation
Sokolov Aleksandr Aleksandrovich – Head of the Ultrasound Research Department
4, Kolomenskiy proezd, Moscow, 115446
S. A. Grashchenko
Russian Federation
Grashchenko Sergey Aleksandrovich – Cand. Of Sci (Med.), Head of the Endoscopy Department
4, Kolomenskiy proezd, Moscow, 115446
References
1. Matsusue E., Fujihara Y., Maeda K., Okamoto M., Yanagitani A., Tanaka K., Nakamura K., & Ogawa T. Three cases of mediastinal pancreatic pseudocysts. Acta radiologica open, 2016, № 5(6), pp. eCollection https://doi.org/10.1177/2058460116647213
2. Manrai M., Kochhar R., Gupta V., Yadav T. D., Dhaka N., Kalra N., Sinha S. K., & Khandelwal N. Outcome of Acute Pancreatic and Peripancreatic Collections Occurring in Patients with Acute Pancreatitis. Annals of surgery, 2018, № 267(2), pp. 357–363. https://doi.org/10.1097/SLA.0000000000002065
3. Bradley E. L., Gonzalez A. C., & Clements J. L. Acute pancreatic pseudocysts: incidence and implications. Annals of surgery, 1976, № 184(6), pp. 734–737. https://doi.org/10.1097/00000658-197612000-00013
4. Lankisch P. G., Weber-Dany B., Maisonneuve P., & Lowenfels A. B. Pancreatic pseudocysts: prognostic factors for their development and their spontaneous resolution in the setting of acute pancreatitis. Pancreatology, 2012, № 12(2), pp. 85–90. https://doi.org/10.1016/j.pan.2012.02.007
5. Krivoruchko I.A., Goncharova N.N. Infected pseudocysts of the pancreas: surgical treatment. Creative Surgery and Oncology, 2019, № 9(1), pp.
6. –25. (In Russ.) https://doi.org/10.24060/2076-3093-2019-9-1-18-25
7. da Costa D. W., Boerma D., van Santvoort H. C., Horvath K. D., Werner J., Carter C. R., Bollen T. L., Gooszen H. G., Besselink M. G., & Bakker O. J. Staged multidisciplinary step-up management for necrotizing pancreatitis. The British journal of surgery, 2014, № 101(1), pp. 65–79. https://doi.org/10.1002/bjs.9346
8. Maatman T. K., Roch A. M., Lewellen K. A., Heimberger M. A., Ceppa E. P., House M. G., Nakeeb A., Schmidt C. M., & Zyromski N. J. Disconnected Pancreatic Duct Syndrome: Spectrum of Operative Management. The Journal of surgical research, 2020, № 247, pp. 297–303. https://doi.org/10.1016/j.jss.2019.09.068
9. Miyauchi M., Suda K., Kuwayama C., Abe H., & Kakinuma C. Role of fibrosis-related genes and pancreatic duct obstruction in rat pancreatitis models: implications for chronic pancreatitis. Histology and histopathology, 2007, № 22(10), pp. 1119–1127. https://doi.org/10.14670/HH-22.1119
10. Vanek P, Trikudanathan G, Freeman ML. Diagnosing Disconnected Pancreatic Duct Syndrome: Many Disconnects, Few Answers. Dig Dis Sci. 10. Dyuzheva T.G., Jus E.V., Shefer A.V., Akhaladze G.G., Chevokin A.Yu., Kotovski A.E., Platonova L.V., Shono N.I., Galperin E.I. Pancreatic necrosis configuration and differentiated management of acute pancreatitis. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2013; № 18 (1), pp. 92–102. (In Russ.)
11. Dyuzheva T.G., Shefer A.V., Dzhus E.V., Tokarev M.V., Stepanchenko A.P., Galperin E.I. Diagnosis of pancreatic duct disruption in acute pancreatitis. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2021, № 26(2), pp. 15–24. (In Russ.) https://doi.org/10.16931/10.16931/1995-5464.2021-2-15-24
12. Nealon W. H., & Walser E. Main pancreatic ductal anatomy can direct choice of modality for treating pancreatic pseudocysts (surgery versus percutaneous drainage). Annals of surgery, 2002, № 235(6), pp. 751–758. https://doi.org/10.1097/00000658-200206000-00001
13. Nealon W. H., Bhutani M., Riall T. S., Raju G., Ozkan O., & Neilan R. A unifying concept: pancreatic ductal anatomy both predicts and determines the major complications resulting from pancreatitis. Journal of the American College of Surgeons, 2009, № 208(5), pp. 790–801. https://doi.org/10.1016/j.jamcollsurg.2008.12.027
14. Galperin E.I., Dyuzheva T.G., Shefer A.V., Kotovskiy A.E., Semenenko I.A., Mudryak D.L. Early interventions for disconnected pancreatic duct syndrome in acute pancreatitis. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery, 2021, № 26(2), pp. 25–31. (In Russ.) https://doi.org/10.16931/1995-5464.2021-2-25-31
15. Acute pancreatitis. Clinical guidelines of the Russian Society of Surgeons and the Association of Hepatobiliary Surgeons of the CIS countries. Moscow, 2020, рр. 54. (in Russ.)
Review
For citations:
Dyuzheva T.G., Mudryak D.L., Semenenko I.A., Shefer A.V., Stepanchenko A.P., Sokolov A.A., Grashchenko S.A. The significance of the criteria for the depth and configuration of pancreatic necrosis in acute pancreatitis in the formation of complicated pseudocysts. Moscow Surgical Journal. 2023;(1):34-42. (In Russ.) https://doi.org/10.17238/2072-3180-2023-1-34-42