Evaluation of the prognostic significance of clinical and biochemical parameters in different forms of acute pancreatitis

Abstract

Introduction. A comprehensive assessment of the nature of the course and severity of acute pancreatitis, based on substantiated prognostic factors, is the most important task of modern clinical medicine.

Objective of the study. To assess the prognostic significance of clinical and biochemical parameters in different forms of acute pancreatitis.

Materials and methods of the study. The study involved 120 patients with acute pancreatitis of varying severity. The average age of the patients was 48±14 years. The following methods were used: collection of anamnesis, clinical, laboratory, instrumental methods.

Treatment results. Mild acute pancreatitis is characterized by the following biochemical features: leukocyte intoxication index (LII) within 6.28±4.5, moderate increase in amylase activity (679.5±67.5 U/l), transaminase levels (AST 126±14.5 U/l, ALT 123±16.1 U/l), C-reactive protein concentration (34.9±6.2 mg/l) and fibrinogen (367±99.8 mg/l). A relatively low diastase level is noted (1531±157 U/l). With a moderate course of the disease, more pronounced deviations in a number of indicators are observed. Severe acute pancreatitis is characterized by the most severe changes in biochemical indicators. A decrease in the concentration of hemoglobin (125±21 g/l) and platelets (205±112×10^9/l) is revealed, which may indicate more pronounced disorders of the hemostasis system.

Conclusion. A comprehensive assessment of laboratory parameters allows stratifying patients by the risk of developing complicated acute pancreatitis with subsequent optimization of treatment tactics.