AGONISTS GONADOTROPIN-RELEASING HORMONE IN THE TREATMENT OF PELVIC PAIN ASSOCIATED WITH ADENOMYOSIS

One of the urgent problems of modern gynecology is pelvic pain, frequency of which is high and the downward trend has not. Genital endome- triosis, particularly adenomyosis diagnosed in 70-90% of women with various symptoms of pelvic pain. The aim of the study was to improve the efficiency of treatment of pelvic pain associated with adenomyosis. Material and methods: Prospective study was conducted at the clinical bases of the Department of obstetrics and gynecology with course perinatologyRUDN- University in the period from October 2017 to May 2018. The study included 30 (n=30) patients of reproductive age with pelvic pain of severeintensity due to adenomyosis, verified on the basis of sonographic and magnetic resonance tomography study. The average age of the surveyed patients withpelvic pain associated with adenomyosis was 33,8 ±0,2 years. All patients were prescribed agonists - GnRH at the 3,75 mg 1 time a month for 3 months. The results of the study: The results showed that after 3 months of treatment of pain is preserved only in 2(6,7%) patients, while pain was of short duration and mild intensity. evaluation of effectiveness after 6 months from the start of treatment demonstrated that mild pain was observed in 6(20,0%) women. After 12 months, pain of low intensity disturbed 9(30,1%) patients and the average algological profile of the severity of the pain made of 0,065±0,02. Conclusion: Pathogenetically justified treatment of pelvic pain of severe intensity associated with adenomyosis should be considered as the application of agonists - GnRH, with the ability to inhibit the neurogenesis in the myometrium, as well as effectively reducing the severity of pain.

adenomyosis, pelvic pain, agonists gonadotropin-releasing hormone

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