Lung transplantation: the state of the issue and prospects
https://doi.org/10.17238/2072-3180-2023-4-88-95
Abstract
Introduction. To date, despite advances in conservative therapy, the only method of treating end-stage lung disease is lung transplantation, which improves the quality and increases the patient's life expectancy. The number of lung transplants is steadily increasing in the world, however, the availability of donor organs is limited, which leads to a high mortality rate of patients on the waiting list. In this regard, there is a constant discussion about donors with expanded criteria, work is underway to improve the preservation of donor lungs, new solutions are being sought for the preservation of the transplant before surgery and the cultivation of bioengineered organs. Along with this, recent advances in post-transplant therapy aimed at combating early and late rejection, graft dysfunction, as well as prevention of infectious complications, contribute to an increase in survival in this category of patients.
The purpose of the study. To study the state of the issue and prospects of lung transplantation.
Materials and methods of research. A review of literary sources among domestic and English-language publications is carried out. Pubmed, Web of Science, RSCI databases were used.
Conclusion. To date, lung transplantation is the only effective treatment method for patients with terminal lung disease. In recent years, there has been a big leap in the field of lung transplantation, clinical experience and post-transplant management of patients are increasing, more and more patients are surviving with transplants that were considered unsuitable several decades ago. Despite the big leap in the field of transplantation, the main problem of the development of lung transplantation is the limited availability of donor organs. To solve the problem of the shortage of donor organs, new technologies (EVLP, bioengineered lungs) are being introduced and criteria for the use of donor organs after circulatory arrest are being expanded.
About the Authors
D. V. Shumakov
Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy
Russian Federation
Russian Federation
Shumakov Dmitry Valerievich – MD, PhD, professor, corresponding member RAS, Head of the Department of Cardiac and Vascular Surgery of the MONIKI named after M.F. Vladimirskii
Schepkina str., 61/2, Moscow, 129110
D. I. Zybin
Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy
Russian Federation
Russian Federation
Zybin Dmitry Igorevich – MD, PhD, Department head of the Cardiac Surgery of the MONIKI named after M.F. Vladimirskii
Schepkina str., 61/2, Moscow, 129110
S. V. Golovinsky
Federal State Budgetary Institution «Research Institute of Pulmonology» of the Federal Medical and Biological Agency
Russian Federation
Russian Federation
Golovinskiy Sergey Vladimirovich – MD, Researcher of the Department Federal State Budgetary Institution «Research Institute of Pulmonology» of the Federal Medical and Biological Agency of Russif
115682 Moscow
M. A. Popov
Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy
Russian Federation
Russian Federation
Popov Mikhail Alexandrovich – MD, PhD, Senior Researcher of the Department of Cardiac Surgery of the MONIKI named after M.F. Vladimirskii
Schepkina str., 61/2, Moscow, 129110
E. G. Agafonov
Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy
Russian Federation
Russian Federation
Agafonov Evgeniy Gennadevich – MD, Researcher of the Department of Cardiac Surgery of the MONIKI named after M.F. Vladimirskii
Schepkina str., 61/2, Moscow, 129110
References
1. Salerno C.T., Burdine J., Perry E.H., Kshettry V.R., Hertz M.I., Bolman R.M., 3rd. Donor-derived antibodies and hemolysis after ABO-compatible but nonidentical heart-lung and lung transplantation. Transplantation, 1998, № 65(2), рр. 261–264. https://doi.org/10.1097/00007890-199801270-00021
2. Wagner W.R., Griffith B.P. Reconstructing the lung. Science, 2010, № 329(5991), рр. 520–522. https://doi.org/10.1126/science.1194087
3. Yeung JCKS.Overview of clinical lung transplantation. Cold Spring Harbor Perspect Med., 2014, № 4(1), рр. a015628. https://doi.org/10.1101/cshperspect.a015628
4. Lund L., Khush K., Cherikh W., Goldfarb S.., Kucheryavaya A, Levvey B. et al. The registry of the international society for heart and lung transplantation: thirty-fourth adult heart transplantation report-2017; focus theme: allograft ischemic time. J Heart Lung Transpl., 2017., № 36(10), рр. 1037–1046. https://doi.org/10.1016/j.healun.2017.07.019
5. Valapour M., Skeans M.A., Heubner B.M. OPTN/SRTR 2013 annual data report: lung. Am J Transplant., 2015, № 15(Suppl 2), рр. 1–28. https://doi.org/10.1111/ajt.13200
6. Weill D. Access to lung transplantation. The long and short of it. Am J RespirCrit Care Med., 2016, № 193(6), рр. 605–606. https://doi.org/10.1164/rccm.201511-2257ED
7. Charles E.J., Huerter M.E., Wagner C.E. Donation after circulatory death lungs transplantable up to six hours after ex vivo lung perfusion. Ann Thorac Surg., 2016, № 102(6), рр. 1845–1853. https://doi.org/10.1016/j.атораксур.2016.06.043
8. Reeb J., Keshavjee S., Cypel M. Expanding the lung donor pool. Curr Opin Organ Transplant., 2015, № 20(5), рр. 498–505. https://doi.org/10.1097/MOT.0000000000000233
9. Krutsinger D, Reed RM, Blevins A. Lung transplantation from donation after cardiocirculatory death: a systematic review and meta-analysis. J Heart Lung Transplant. 2015;34(5):675–684. https://doi.org/10.1016/j.healun.2014.11.009
10. Kootstra G., Daemen J.H., Oomen A.P. “Categories of non-heartbeating donors”. Transplantation Proceedings, 1995, № 27(5), рр. 2893–2894. https://doi.org/10.1016/j.nephro.2007.06.017
11. Aigner C., Winkler G., Jaksch P. Extended donor criteria for lung transplantation—a clinical reality. Eur J Cardiothorac Surg., 2005, № 27(5), рр. 757–761. https://doi.org/10.1016/j.ejcts.2005.01.024
12. Tikkanen J.M., Cypel M., Machuca T.N. Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation. J Heart Lung Transplant., 2015, № 34(4), рр. 547–556. https://doi.org/10.1016/j.healun.2014.09.044
13. Somers J., Ruttens D., Verleden S.E. A decade of extended-criteria lung donors in a single center: Was it justified? Transpl Int., 2015, № 28(2), рр. 170–179. https://doi.org/10.1111/tri.12470
14. Dorrello N.V., Guenthart B.A., O’Neill J.D. Functional vascularized lung grafts for lung bioengineering. Sci Adv., 2017, № 3(8), рр. e1700521. https://doi.org/10.1126/sciadv.1700521
15. Meers C., Van Raemdonck D., Verleden G.M. The number of lung transplants can be safely doubled using extended criteria donors; a single-center review. Transpl Int., 2010, № 23(6), рр. 628–635. https://doi.org/10.1111/j.1432-2277.2009.01033
16. Sommer W., Kühn C., Tudorache I. Extended criteria donor lungs and clinical outcome: results of an alternative allocation algorithm. J Heart Lung Transplant., 2013, № 32(11), рр. 1065–1072. https://doi.org/10.1016/j.healun.2013.06.021
17. Taaning E, Morling N, Mortensen SA, Pettersson G, Simonsen AC. Severe hemolysis caused by graft-derived anti-B production after lung transplantation. J Heart Lung Transpl. 1996;15(8):850–851.
18. DemirA., Coosemans W., Decaluwe H., De Leyn .P, Nafteux P., Van Veer H. et al. Donor-recipient matching in lung transplantation: which variables are important? Eur J Cardiothorac Surg., 2015, № 47(6), рр. 974–983. https://doi.org/10.1093/ejcts/ezu340
19. Fakhro M. ABO-identical matching has no superiority in long-term survival in comparison to ABO-compatible matching in lung transplantation. J Cardiothorac Surg., 2019, № 14, рр. 24. https://doi.org/10.1186/s13019-019-0846-6
20. Bonser R.S., Taylor R., Collett D., Thomas H.L., Dark J.H., Neuberger J. Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry. Lancet, 2012, № 380(9843), рр. 747–755. https://doi.org/10.1016/S0140-6736(12)60160-3
21. Munshi L., Keshavjee S., Cypel M. Donor management and lung preservation for lung transplantation. Lancet Respir Med., 2013, № 1(4), рр. 318–328. https://doi.org/10.1016/S2213-2600(12)70064-4
22. Gomez-de-Antonio D., Campo-Cañaveral J.L., Crowley S. Clinical lung transplantation from uncontrolled non–heart-beating donors revisited. J Heart Lung Transplant., 2012, № 31(4), рр. 349–353. https://doi.org/10.1016/j.healun.2011.12.007.
23. Meneses J.C., Gámez P., Mariscal A. Development of a non–heart-beating donor program and results after the first year. Transplant Proc., 2012, № 44(7), рр. 2047–2049. https://doi.org/10.1016/j.transproceed.2012.07.092
24. Machuca T.N., Cypel M. Ex vivo lung perfusion. J Thorac Dis., 2014, № 6(8), р. 1054–1062. https://doi.org/10.3978/j.issn.2072-1439.2014.07.12
25. Ware L.B., Wang Y., Fang X., Warnock M., Sakuma T., Hall T.S. et al. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet, 2002, № 360, рр. 619–620. https://doi.org/10.1016/s0140-6736(02)09774-x
26. Hozain A.E., Tipograf Yu., Pinezich M.R., O’Neill J.D., Vunjak-Novakovic G., Bacchetta M. Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine. Thoracic: Lung Transplantation, 2020, № 159(4). https://doi.org/10.1016/j.jtcvs.2019.09.121
27. Boffini M., Ricci D., Bonato R., Fanelli V., Attisani M., Ribezzo M. et al. Incidence and severity of primary graft dysfunction after lung transplantation using rejected grafts reconditioned with ex vivo lung perfusion. Eur J Cardiothorac Surg., 2014, № 46, рр. 789–793. https://doi.org/10.1093/ejcts/ezu239
28. Kugler C., Gottlieb J., Warnecke G., Schwarz A., Weissenborn K., Barg-Hock H. et al. Health-related quality of life after solid organ transplantation: a prospective, multiorgan cohort study. Transplant J., 2013, № 96, рр. 316–323. https://doi.org/10.1097/TP.0b013e31829853eb
29. Wobma H., Vunjak-Novakovic G. Tissue engineering and regenerative medicine 2015: a year in review. Tissue Eng Part B Rev., 2016, № 22(2), рр. 101–113. https://doi.org/10.1089/ten.TEB.2015.0535
30. Nichols J.E., La Francesca S., Niles J.A., Vega S.P., Argueta L.B., Frank L. et.al. Production and transplantation of bioengineered lung into a large-animal model. Science Translational Medicine, 2018, № 10(452). https://doi.org/10.1126/scitranslmed.aao3926
Review
For citations:
Shumakov D.V., Zybin D.I., Golovinsky S.V., Popov M.A., Agafonov E.G. Lung transplantation: the state of the issue and prospects. Moscow Surgical Journal. 2023;(4):88-95. (In Russ.) https://doi.org/10.17238/2072-3180-2023-4-88-95
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