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Controlled minimally invasive surgical interventions in the treatment of patients with benign thyroid gland nodules with increased volume. (Literature Review part I)

https://doi.org/10.17238/2072-3180-2025-4-235-243

Abstract

This literature review presents a systematic evaluation of contemporary studies, encompassing representative works dedicated to various methods of managing thyroid nodules with increased volume under ultrasound guidance. Special attention is given to the fundamental principles of performing interventions and to the analysis of technologies applied in hyperthermic (laser, radiofrequency, ultrasound, and microwave ablation), chemical (percutaneous ethanol injection, percutaneous polidocanol injection) and mixed (photodynamic therapy) ablations. The review also provides a comparative analysis of controlled minimally invasive treatment methods for the benign thyroid nodules with increased volume, with the aim of assessing their clinical efficacy and safety, as well as feasibility of selecting these methods as alternatives to traditional surgical interventions.

About the Authors

D. D. Dolidze
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health; FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation
Russian Federation

Dolidze David Jonovich – Doctor of Medical Sciences, Professor, Head of the Scientific and Clinical Department; Professor, Department of Surgery, Transplantology, and Applied Oncology 

5, 2nd Botkinsky pr-d, Moscow, 125284;
2/1, Barrikadnaya str., Moscow, 123995



Z. A. Bagatelia
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health; FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation
Russian Federation

Bagatelia Zurab Antonovich – Doctor of Medical Sciences, Professor, First Deputy Director; Professor, Department of Surgery, Transplantology, and Applied Oncology 

5, 2nd Botkinsky pr-d, Moscow, 125284;
2/1, Barrikadnaya str., Moscow, 123995



A. A. Shchegolev
Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Pirogov University)
Russian Federation

Shchegolev Alexander Alexandrovich – Doctor of Medical Sciences, Professor, Head of the Department of Hospital Surgery of the Pediatric Faculty 

1, Ostrovityanova str., Moscow, 117513;



P. A. Drozdov
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health; FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation
Russian Federation

Drozdov Pavel Alekseevich – Doctor of Medical Sciences, Associate Professor, Deputy Director for Research; Associate Professor, Department of Surgery, Transplantology, and Applied Oncology 

5, 2nd Botkinsky pr-d, Moscow, 125284;
2/1, Barrikadnaya str., Moscow, 123995



S. H. Laboyan
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health
Russian Federation

Laboyan Suren Hamletovich – Junior Researcher 

5, 2nd Botkinsky pr-d, Moscow, 125284



A. V. Vardanyan
FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation
Russian Federation

Vardanyan Arshak Vardanovich – Doctor of Medical Sciences, Professor, Department of Surgery, Transplantology, and Applied Oncology 

2/1, Barrikadnaya str., Moscow, 123995



K. S. Titov
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health; Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"
Russian Federation

Titov Konstantin Sergeyevich – Doctor of Medical Sciences, Professor, Leading Researcher; Professor of the Department of Oncology and Roentgenology named after Academician V.P. Kharchenko 

5, 2nd Botkinsky pr-d, Moscow, 125284;
6, Miklukho-Maklaya str., Moscow, 117198



I. N. Lebedinsky
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health
Russian Federation

Lebedinsky Ivan Nikolaevich – Candidate of Medical Sciences, senior research fellow, head of Oncosurgical Department No. 71 (General Oncology) 

5, 2nd Botkinsky pr-d, Moscow, 125284



G. G. Melkonyan
FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation; Moscow 5GBUZ "Hospital for War Veterans № 3 of the Moscow Department of Health"
Russian Federation

Melkonyan George Gennadievich – Doctor of Medical Sciences, Professor, Chief Physician; Professor, Department of Combined and Multiple Trauma 

4, Startovaya str., Moscow, 129336;
2/1, Barrikadnaya str., Moscow, 123995;



N. N. Gogitidze
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health
Russian Federation

Gogitidze Nodar Nodarovich – Candidate of Medical Sciences, Head of Diagnostic Department № 8 

5, 2nd Botkinsky pr-d, Moscow, 125284



A. Y. Lukin
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health; FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation
Russian Federation

Lukin Andrey Yurievich – Doctor of Medical Sciences, Professor, deputy chief physician for outpatient and polyclinic work; Professor, Department of Surgery, Transplantology, and Applied Oncology 

5, 2nd Botkinsky pr-d, Moscow, 125284;
2/1, Barrikadnaya str., Moscow, 123995



A. R. Oganyan
"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health
Russian Federation

Oganyan Armen Robertovich – Candidate of Medical Sciences, Head of the Operating Room Department 

5, 2nd Botkinsky prd, Moscow, 125284



L. L. Dzhikiia
Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation

Dzhikiia Louise Levanovna – sixth-year student of the faculty of the N.V. Sklifosovsky Institute of Clinical Medicine, specializing in General Medicine 

2–4, Bolshaya Pirogovskaya str., Moscow, 119435



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Review

For citations:


Dolidze D.D., Bagatelia Z.A., Shchegolev A.A., Drozdov P.A., Laboyan S.H., Vardanyan A.V., Titov K.S., Lebedinsky I.N., Melkonyan G.G., Gogitidze N.N., Lukin A.Y., Oganyan A.R., Dzhikiia L.L. Controlled minimally invasive surgical interventions in the treatment of patients with benign thyroid gland nodules with increased volume. (Literature Review part I). Moscow Surgical Journal. 2025;(4):235-243. (In Russ.) https://doi.org/10.17238/2072-3180-2025-4-235-243

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