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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mossj</journal-id><journal-title-group><journal-title xml:lang="ru">Московский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Moscow Surgical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-3180</issn><publisher><publisher-name>ООО «ПРОФИЛЬ – 2С»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/2072-3180-2025-4-235-243</article-id><article-id custom-type="elpub" pub-id-type="custom">mossj-1109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛИТЕРАТУРНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERARY REVIEWS</subject></subj-group></article-categories><title-group><article-title>Контролируемые малоинвазивные хирургические вмешательства в лечении пациентов с доброкачественными объемными образованиями щитовидной железы. (Обзор литературы часть I)</article-title><trans-title-group xml:lang="en"><trans-title>Controlled minimally invasive surgical interventions in the treatment of patients with benign thyroid gland nodules with increased volume. (Literature Review part I)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0517-8540</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долидзе</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolidze</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Долидзе Давид Джонович – доктор медицинских наук, профессор, ученый секретарь, заведующий научно-клиническим отделом; профессор кафедры хирургии трансплантологии и прикладной онкологии </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5;123995, г. Москва, ул. Баррикадная, д. 2/1</p></bio><bio xml:lang="en"><p>Dolidze David Jonovich – Doctor of Medical Sciences, Professor, Head of the Scientific and Clinical Department; Professor, Department of Surgery, Transplantology, and Applied Oncology </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284; 2/1, Barrikadnaya str., Moscow, 123995</p></bio><email xlink:type="simple">ddolidzed@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5699-3695</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багателия</surname><given-names>З. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagatelia</surname><given-names>Z. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Багателия Зураб Антонович – доктор медицинских наук, профессор, первый заместитель директора; профессор кафедры хирургии трансплантологии и прикладной онкологии </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5;123995, г. Москва, ул. Баррикадная, д. 2/1</p></bio><bio xml:lang="en"><p>Bagatelia Zurab Antonovich – Doctor of Medical Sciences, Professor, First Deputy Director; Professor, Department of Surgery, Transplantology, and Applied Oncology </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284; 2/1, Barrikadnaya str., Moscow, 123995</p></bio><email xlink:type="simple">bagateliaz@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6427-4295</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щеголев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchegolev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щеголев Александр Александрович – доктор медицинских наук, профессор, заведующий кафедрой госпитальной хирургии педиатрического факультета </p><p>117513, г. Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Shchegolev Alexander Alexandrovich – Doctor of Medical Sciences, Professor, Head of the Department of Hospital Surgery of the Pediatric Faculty </p><p>1, Ostrovityanova str., Moscow, 117513;</p></bio><email xlink:type="simple">ashegolev57@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8016-1610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дроздов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Drozdov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дроздов Павел Алексеевич – доктор медицинских наук, доцент, заместитель директора по научной работе; доцент кафедры хирургии трансплантологии и прикладной онкологии </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5; 123995, г. Москва, ул. Баррикадная, д. 2/1 </p></bio><bio xml:lang="en"><p>Drozdov Pavel Alekseevich – Doctor of Medical Sciences, Associate Professor, Deputy Director for Research; Associate Professor, Department of Surgery, Transplantology, and Applied Oncology </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284;2/1, Barrikadnaya str., Moscow, 123995</p></bio><email xlink:type="simple">dc.drozdov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-6319-4318</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лабоян</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Laboyan</surname><given-names>S. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лабоян Сурен Гамлетович – младший научный сотрудник </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Laboyan Suren Hamletovich – Junior Researcher </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284</p></bio><email xlink:type="simple">s-leon81@hotmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0893-3740</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варданян</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vardanyan</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Варданян Аршак Варданович – доктор медицинский наук, профессор кафедры хирургии трансплантологии и прикладной онкологии </p><p>123995, г. Москва, ул. Баррикадная, д. 2/1</p></bio><bio xml:lang="en"><p>Vardanyan Arshak Vardanovich – Doctor of Medical Sciences, Professor, Department of Surgery, Transplantology, and Applied Oncology </p><p>2/1, Barrikadnaya str., Moscow, 123995</p></bio><email xlink:type="simple">vardanyan-med@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4460-9136</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титов</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Titov</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Титов Константин Сергеевич – доктор медицинский наук, профессор, ведущий научный сотрудник; профессор кафедры онкологии и рентгенорадиологии им. В.П. Харченко Медицинского института AuthorID: 921470 </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5;117198, г. Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Titov Konstantin Sergeyevich – Doctor of Medical Sciences, Professor, Leading Researcher; Professor of the Department of Oncology and Roentgenology named after Academician V.P. Kharchenko </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284;6, Miklukho-Maklaya str., Moscow, 117198</p></bio><email xlink:type="simple">ks-titov@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7735-1106</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебединский</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedinsky</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебединский Иван Николаевич – кандидат медицинских наук, старший научный сотрудник, заведующий онкохирургическим отделением №71 (общей онкологии) </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Lebedinsky Ivan Nikolaevich – Candidate of Medical Sciences, senior research fellow, head of Oncosurgical Department No. 71 (General Oncology) </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284</p></bio><email xlink:type="simple">ivan-lebedinskiy@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7234-4185</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелконян</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Melkonyan</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мелконян Георгий Геннадьевич – доктор медицинский наук, профессор, главный врач; профессор кафедры сочетанных и комбинированных повреждений </p><p>129336, г. Москва, ул. Стартовая, д. 4;123995, г. Москва, ул. Баррикадная, д. 2/1</p></bio><bio xml:lang="en"><p>Melkonyan George Gennadievich – Doctor of Medical Sciences, Professor, Chief Physician; Professor, Department of Combined and Multiple Trauma </p><p>4, Startovaya str., Moscow, 129336; 2/1, Barrikadnaya str., Moscow, 123995;</p></bio><email xlink:type="simple">glav@gkb4.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-8815-9453</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гогитидзе</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gogitidze</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гогитидзе Нодар Нодарович – кандидат медицинских наук, заведующий диагностическим отделением №8 </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Gogitidze Nodar Nodarovich – Candidate of Medical Sciences, Head of Diagnostic Department № 8 </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284</p></bio><email xlink:type="simple">gogitidzenn@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3199-5253</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукин</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukin</surname><given-names>A. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лукин Андрей Юрьевич – доктор медицинских наук, профессор, ведущий научный сотрудник, заместитель главного врача по амбулаторно-поликлинической работе; профессор кафедры хирургии трансплантологии и прикладной онкологии  </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5;123995, г. Москва, ул. Баррикадная, д. 2/1</p></bio><bio xml:lang="en"><p>Lukin Andrey Yurievich – Doctor of Medical Sciences, Professor, deputy chief physician for outpatient and polyclinic work; Professor, Department of Surgery, Transplantology, and Applied Oncology </p><p>5, 2nd Botkinsky pr-d, Moscow, 125284; 2/1, Barrikadnaya str., Moscow, 123995</p></bio><email xlink:type="simple">onion_lay@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-8552-4272</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оганян</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Oganyan</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оганян Армен Робертович – кандидат медицинских наук, заведующий операционным блоком </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Oganyan Armen Robertovich – Candidate of Medical Sciences, Head of the Operating Room Department </p><p>5, 2nd Botkinsky prd, Moscow, 125284</p></bio><email xlink:type="simple">aoganian@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-5208-304X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джикия</surname><given-names>Л. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhikiia</surname><given-names>L. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джикия Луиза Левановна – студент VI курса факультета «Институт клинической медицины им. Н.В. Склифосовского» по специальности «Лечебное дело» </p><p>119435, г. Москва, ул. Большая Пироговская, д. 2, стр. 4</p></bio><bio xml:lang="en"><p>Dzhikiia Louise Levanovna – sixth-year student of the faculty of the N.V. Sklifosovsky Institute of Clinical Medicine, specializing in General Medicine </p><p>2–4, Bolshaya Pirogovskaya str., Moscow, 119435</p></bio><email xlink:type="simple">luiza.01@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>«Московский многопрофильный научно-клинический центр им. С.П. Боткина» Департамента здравоохранения г. Москвы;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health;&#13;
FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России (Пироговский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Pirogov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>«Московский многопрофильный научно-клинический центр им. С.П. Боткина» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>«Московский многопрофильный научно-клинический центр им. С.П. Боткина» Департамента здравоохранения г. Москвы;&#13;
Федеральное государственное автономное образовательное учреждения высшего образования «Российский университет дружбы народов им. Патриса Лумумбы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>"Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin" of the Moscow Department of Health;&#13;
Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации;&#13;
ГБУЗ г. Москвы «Госпиталь для ветеранов войн № 3 Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FGBOU DPO "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation;&#13;
Moscow 5GBUZ "Hospital for War Veterans № 3 of the Moscow Department of Health"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>235</fpage><lpage>243</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Долидзе Д.Д., Багателия З.А., Щеголев А.А., Дроздов П.А., Лабоян С.Г., Варданян А.В., Титов К.С., Лебединский И.Н., Мелконян Г.Г., Гогитидзе Н.Н., Лукин А.Ю., Оганян А.Р., Джикия Л.Л., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Долидзе Д.Д., Багателия З.А., Щеголев А.А., Дроздов П.А., Лабоян С.Г., Варданян А.В., Титов К.С., Лебединский И.Н., Мелконян Г.Г., Гогитидзе Н.Н., Лукин А.Ю., Оганян А.Р., Джикия Л.Л.</copyright-holder><copyright-holder xml:lang="en">Dolidze D.D., Bagatelia Z.A., Shchegolev A.A., Drozdov P.A., Laboyan S.H., Vardanyan A.V., Titov K.S., Lebedinsky I.N., Melkonyan G.G., Gogitidze N.N., Lukin A.Y., Oganyan A.R., Dzhikiia L.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mossj.ru/jour/article/view/1109">https://www.mossj.ru/jour/article/view/1109</self-uri><abstract><p>В настоящем обзоре литературы представлена систематическая оценка современных исследований, охватывающих репрезентативные работы, посвященные различным методам воздействия на объемные образования щитовидной железы под контролем ультразвука. Особое внимание уделяется основным принципам выполнения вмешательств и анализу технологий, применяемых при гипертермических (лазерная, радиочастотная, ультразвуковая и микроволновая абляции), химических (чрескожная инъекция этанолом, чрескожная инъекция полидоканолом) и смешанных (фотодинамическая терапия) абляциях. В обзоре также представлен сравнительный анализ контролируемых малоинвазивных методов лечения доброкачественных объемных образований щитовидной железы с целью оценки их клинической эффективности и безопасности, а также возможности выбора этих методов в качестве альтернативы традиционному хирургическому вмешательству.</p></abstract><trans-abstract xml:lang="en"><p>This literature review presents a systematic evaluation of contemporary studies, encompassing representative works dedicated to various methods of managing thyroid nodules with increased volume under ultrasound guidance. Special attention is given to the fundamental principles of performing interventions and to the analysis of technologies applied in hyperthermic (laser, radiofrequency, ultrasound, and microwave ablation), chemical (percutaneous ethanol injection, percutaneous polidocanol injection) and mixed (photodynamic therapy) ablations. The review also provides a comparative analysis of controlled minimally invasive treatment methods for the benign thyroid nodules with increased volume, with the aim of assessing their clinical efficacy and safety, as well as feasibility of selecting these methods as alternatives to traditional surgical interventions.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>химическая абляция (чрескожная инъекция этанолом</kwd><kwd>чрескожная инъекция полидоканолом – ЧИЭ</kwd><kwd>ЧИП)</kwd><kwd>лазерная абляция (ЛА)</kwd><kwd>радиочастотная абляция (РЧА)</kwd><kwd>ультразвуковая абляция (воздействие высокоинтенсивным сфокусированным ультразвуком – ВВСУ)</kwd><kwd>микроволновая абляция (МВА)</kwd><kwd>смешанная абляция (фотодинамическая терапия – ФДТ)</kwd><kwd>коэффициент уменьшения объема (КУО)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chemical ablation (percutaneous ethanol injection</kwd><kwd>percutaneous polidocanol injection – PEI</kwd><kwd>PPI)</kwd><kwd>laser ablation (LA)</kwd><kwd>radiofrequency ablation (RFA)</kwd><kwd>ultrasound ablation (high-intensity focused ultrasound – HIFU)</kwd><kwd>microwave ablation (MWA)</kwd><kwd>mixed ablation (photodynamic therapy – PDT)</kwd><kwd>volume reduction rate (VRR)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Трошина Е.А., Платонова Н.М., Панфилова Е.А. 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