Mediastinal Tumors: Classification, Pathogenesis, and Modern Approaches to Diagnosis and Treatment
https://doi.org/10.17238/2072-3180-2025-4-222-227
Abstract
Introduction. The relevance of the study of tumors of the plexus is due to the optimization of diagnosis and improvement of treatment efficiency of patients with these neoplasms, as well as the choice of optimal treatment tactics.
Materials and Methods. For the analysis, various databases were used, including MedLine, Science Direct, PubMed, and eLIBRARY.ru. The search was conducted using keywords. Research methods included analytical analysis and generalization of data.
Results. The choice of surgical treatment should be based on a thorough evaluation of each individual case. According to clinical guidelines, thoracoscopy is preferred for tumors measuring 2–5 cm, availability of an experienced surgical team, and absence of severe comorbid pathology. Open surgeries remain the method of choice for giant leiomyomas, central localization near the cardia, and cases combined with other esophageal diseases.
Conclusion. Modern studies confirm that thoracoscopic techniques provide comparable radicality with significantly reduced invasiveness when patients are properly selected. However, the final decision must consider all clinical factors and the technical capabilities of the medical facility. Open surgeries remain relevant for giant tumors and complex localizations. Current evidence demonstrates that thoracoscopic approaches, under appropriate patient selection, achieve equivalent efficacy while minimizing procedural trauma
About the Authors
A. D. KhamaraRussian Federation
Khmara Artem Dmitrievich – Candidate of Medical Sciences, surgeon at the Thoracic Surgical Department
410012, Bolshaya Kazachya St., 112, Saratov
S. V. Kapralov
Russian Federation
Kapralov Sergey Vladimirovich – Doctor of Medicine Sciences, associate professor, Head of the Department of Faculty Surgery and Oncology
410012, Bolshaya Kazachya St., 112, Saratov
M. A. Polidanov
Russian Federation
Polidanov Maxim Andreevich – Research department specialist, assistant of the Department of Biomedical Disciplines
198099, Kalinina St., 8, bld. 2, lit. A, Saint Petersburg
M. S. Lebedev
Russian Federation
Lebedev Maksim Sergeevich – Candidate of Medical Sciences, surgeon at the Thoracic Surgical Department
410012, Bolshaya Kazachya St., 112, Saratov
V. V. Maslyakov
Russian Federation
Maslyakov Vladimir Vladimirovich – Doctor of Medical Sciences, Professor, Professor of the Department of Mobilization Preparedness in Healthcare and Disaster Medicine
410012, Bolshaya Kazachya St., 112, Saratov
P. B. Tsvkanova
Russian Federation
Tsukanova Polina Borisovna – 3-rd year student, Faculty of Medicine
198099, Kalinina St., 8, bld. 2, lit. A, Saint Petersburg
K. A. Volkov
Russian Federation
Volkov Kirill Andreevich – 4-th year student at the Institute of Clinical Medicine
410012, Bolshaya Kazachya St., 112, Saratov
A. A. Kashikhin
Russian Federation
Kashihin Andrey Andreevich – 4-th year student, Faculty of Medicine
198099, Kalinina St., 8, bld. 2, lit. A, Saint Petersburg
E. N. Kotenko
Russian Federation
Kotenko Elena Nikolaevna – 3-rd year student of the Dental Faculty
198099, Kalinina St., 8, bld. 2, lit. A, Saint Petersburg
R. Sh. Rasulova
Russian Federation
Rasulova Raziyahalum Shamilovna – 2-nd-year student of the Dental Institute
410012, Bolshaya Kazachya St., 112, Saratov
References
1. Shields, T.W. Mediastinal tumors: Clinical presentation and management. Annals of Thoracic Surgery, 2018, vol. 105, № 2, P. 345–356.
2. Alexandrov O.A., Ryabov A.B., Pikin O.V. Thymoma: A Literature Review. Siberian Journal of Oncology, 2017, Vol. 16, № 4, рр. 76–83. (In Russ.)
3. Carter B.W., Marom E.M. Imaging of mediastinal tumors. Radiologic Clinics, 2021, vol. 59, № 2, рр. 241–254.
4. Moran C.A., Kalhor N., Suster S., Weissferdt A. Neurogenic tumors of the mediastinum: A comprehensive review with emphasis on multidisciplinary approach. Annals of Diagnostic Pathology, 2023, № 62, рр. 152–163.
5. Stachowicz-Stencel T. Pediatric mediastinal tumors: Epidemiology and treatment challenges. Journal of Pediatric Oncology, 2023, vol. 41, № 2, рр. 78–92.
6. Duwe B.V., Sterman D.H., Musani A.I. Tumors of the mediastinum: Part I. Chest, 2023, vol. 163, № 1, рр. 211–226.
7. Kolbanov K.I. et al. Mediastinal Tumors: Classifications. Oncology. Journal of P.A. Herzen, 2019, Vol. 8, № 6, Р. 471–478. (In Russ.)
8. Travis W.D., Brambilla E., Burke A.P., Marx А., Nicholson A.G. Introduction to the 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart. J Thorac Oncol, 2015, vol. 10, № 9, рр. 1240–1242.
9. Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., Thiele J. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th ed.). International Agency for Research on Cancer, 2023, 586 р.
10. Filosso P.L., Sandri A., Guerrera F., Lausi P.O., Lyberis P., Ruffini E. Neurogenic tumors of the mediastinum: Clinical presentation and surgical outcomes. Journal of Thoracic Disease, 2022, vol. 14, № 5, рр. 1567–1578.
11. Stachowicz-Stencel T., Orbach D. Pediatric mediastinal tumors: Diagnostic and therapeutic challenges. Frontiers in Pediatrics, 2021, № 9, 703506.
12. Cohen M., Rizzo S. Asymptomatic mediastinal masses: When to intervene? Chest, 2019, vol. 156, № 4, рр. 789–798.
13. Duwe B.V., Sterman D.H., Musani A.I. Tumors of the mediastinum. Chest, 2005, vol. 128, № 4, рр. 2893–909.
14. Carter B.W., Tomiyama N. Modern imaging of mediastinal tumors. Radiologic Clinics, 2022, vol. 60, № 3, рр. 421–435.
15. Ryabov A.B. and others. A clinical algorithm for the diagnosis and treatment of mediastinal tumors. Surgery. N. I. Pirogov Journal, 2022, № 5, рр. 43–51. (In Russ.).
Review
For citations:
Khamara A.D., Kapralov S.V., Polidanov M.A., Lebedev M.S., Maslyakov V.V., Tsvkanova P.B., Volkov K.A., Kashikhin A.A., Kotenko E.N., Rasulova R.Sh. Mediastinal Tumors: Classification, Pathogenesis, and Modern Approaches to Diagnosis and Treatment. Moscow Surgical Journal. 2025;(4):222-227. (In Russ.) https://doi.org/10.17238/2072-3180-2025-4-222-227

















