Diagnostic value of atomic force microscopy of erythrocytes of patients with pancreatic necrosis
https://doi.org/10.17238/2072-3180-2025-1-49-55
Abstract
Introduction. The relevance of the problem of pancreatic necrosis is that currently the number of diseases, including severe forms, is steadily increasing.
Purpose. To improve the results of early diagnosis of pancreatic necrosis by studying the membranes of red blood cells.
Materials and methods. The erythrocyte membrane was examined using atomic electron microscopy. Additionally, neutrophilic erythrocytes were studied using this method. The study included 17 patients with pancreatic necrosis.
Results. The study conducted by atomic electron microscopy in patients with pancreatic necrosis revealed changes in the membrane of erythrocytes and the shape of the nucleus and the state of the cytoplasm of neutrophilic leukocytes.
Conclusions. The study of the erythrocyte membrane and the state of neutrophilic leukocytes by atomic electron microscopy in patients with pancreatic necrosis makes it possible to identify early changes in the absence of clinical manifestations and predict the possibility of purulent septic complications.
About the Authors
G. N. Gulikyan
University "Clinical hospital "Russian Railways-Medicine" of the city of Krasnoyarsk"
Russian Federation
Russian Federation
Gulikyan Garen Norayrovich, PhD, Associate Professor of Plastic Surgery at Rosbiotech
47 Lomonosova St., Krasnoyarsk, 660058
R. A. Pakhomova
FGBOU IN Rosbiotech
Russian Federation
Russian Federation
Pakhomova Regina Alexandrovna, MD, Head of the Department of Plastic Surgery at Rosbiotech
11, Volokolamsk Highway, Moscow, 125080
V. V. Kozlov
Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Kozlov Vasily Vladimirovich, Candidate of Medical Sciences, Associate Professor of the Department of Occupational Diseases
8 Trubetskaya str., building 2, Moscow, 119991
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Review
For citations:
Gulikyan G.N., Pakhomova R.A., Kozlov V.V. Diagnostic value of atomic force microscopy of erythrocytes of patients with pancreatic necrosis. Moscow Surgical Journal. 2025;(1):49-55. (In Russ.) https://doi.org/10.17238/2072-3180-2025-1-49-55
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