Modern methods and preparations for regeneration liver and mechanisms of their action in liver resections

Introduction. Preoperative assessment of the risks of liver failure and the study of the process of reparative liver regeneration play a key role in choosing the scope of surgery. The study of the features of postresection liver regeneration will also allow us to assess the possibility and necessity of using regenerative medicine methods, including those based on the use of stem cells and gene therapy.

The purpose of the study. To analyze modern approaches to stimulation of postresection liver regeneration, to study the mechanisms of their effect.

Materials and methods of research. The data presented in PubMed, Elibrary and Cyberleninka are reviewed. Criteria for exclusion from the analysis: description of individual clinical cases; books and documents; comparison of treatment results of individual patients. The final analysis includes 52 works from the initially identified 105 sources.

Results. To date, there are several ways to influence liver regeneration: the ERAS technique, the study of the functional reserve of the liver, components of the hemostasis system, infusion therapy, correction of its own metabolites, regulation of signaling repair pathways. One of the most promising approaches is the use of multipotent stem cells.

Conclusion. The study and understanding of modern mechanisms for increasing the reparative potential of the liver will allow not only to perform extensive surgical interventions with fewer complications, but also to reduce the recovery time and disability of patients after such interventions.

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