Changes in the surface of erythrocytes in patients with mild acute pancreatitis
https://doi.org/10.17238/2072-3180-2024-2-23-27
Abstract
Introduction. Acute pancreatitis is one of the most severe surgical diseases, often leading to death. An in-depth study of the pathogenesis of acute pancreatitis has not only theoretical but also practical significance.
The purpose of the work: to study changes in the plasma membrane of the erythrocyte with varying degrees of severity of acute pancreatitis, in order to further use it for early diagnosis of pancreatic necrosis.
Materials and methods. The study included 32 patients with mild acute pancreatitis. The erythrocytes of patients with mild acute pancreatitis were compared with the erythrocytes of practically healthy people. For the study, electron microscopy of erythrocytes with additional atomic force microscopy was performed.
Conclusion. According to the conducted research, it seems possible to assume that an increase in the number of lipid peroxidation products in the erythrocyte membrane leads to deformation of its surface. In patients with mild acute pancreatitis, defects (erosion) of the plasma membrane of the erythrocyte are noted. The use of AFM to assess the microstructure of the erythrocyte can be recommended for early prediction of the development of pancreatic necrosis.
About the Authors
G. N. Gulikyan
Clinical hospital "RZD-Medicine" city Krasnoyarsk
Russian Federation
Russian Federation
Gulikyan Garen Norairovich – PhD, Head of the Department of Plastic Surgery
660058, Krasnoyarsk, Lomonosov str., 47
R. А. Pakhomova
Federal State Budgetary Educational Institution of Higher Education "Russian Biotechnological University"
Russian Federation
Russian Federation
Pakhomova Regina Alexandrovna – MD, Head of the Department of Plastic Surgery
11, Volokolamsk Highway, Moscow, 125080
V. V. Kozlov
Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Kozlov Vasily Vladimirovich – Ph.D., Associate Professor of the Department
8 Trubetskaya str., building 2, Moscow, 119991
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For citations:
Gulikyan G.N., Pakhomova R.А., Kozlov V.V. Changes in the surface of erythrocytes in patients with mild acute pancreatitis. Moscow Surgical Journal. 2024;(2):23-27. (In Russ.) https://doi.org/10.17238/2072-3180-2024-2-23-27
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