Prospects for improving laboratory diagnostics of disorders of mesenteric circulation

Violation of the mesenteric circulation, including both acute and chronic forms, still remains an important difcult-to-diagnose surgical problem, accompanied by high mortality rates. Te share of various forms of mesenteric ischemia accounts for about 1:1000 emergency hospitalizations in Europe and the United States, and in Japan this fgure is estimated at 1:10,000. According to the literature data, it is known that CIOP syndrome is established only in 16,6 % of patients, and then only afer lengthy examinations. In 60 % of patients with CIOP syndrome, acute mesenteric insufciency develops, the mortality from which is 65–95 %.

Tis literature review was carried out in order to fnd the most informative method for early laboratory diagnosis of intestinal ischemia. Te necessity to minimize the diagnosis time of mesenteric ischemia, drives studies aimed to create new markers that, by changing their concentration, indicate ischemia of the intestinal wall and make it possible to perform surgical treatment as soon as possible.

A similar diagnostic potential has a laboratory indicator - the intestinal form of an intestinal fatty acid binding protein (I-FABP), the sensitivity and specificity of which, according to various authors, is 80 % and 85 %, [18] and 79% and 91,3 % [19], respectively.

Te study of I-FABP is promising, and optimization of the algorithm for diagnosing patients with suspected mesenteric circulatory disorders by determining the level of this marker will help reduce the time for diagnosing this pathology, improve the results of treatment of patients, their quality of life in the postoperative period, and reduce mortality.

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