Preview

Moscow Surgical Journal

Advanced search

The impact of frailty on outcomes of minimally invasive laparoscopic surgery in elderly patients: a scoping review

https://doi.org/10.17238/2072-3180-2025-4-179-194

Abstract

Introduction. Aging is accompanied by a growing number of patients requiring surgical treatment, necessitating a reassessment of traditional approaches to preoperative risk stratification. In recent years, the concept of frailty has gained significant attention as a key factor influencing surgical outcomes. Frailty is characterized by a decline in physiological reserves, leading to an increased risk of postoperative complications, prolonged hospitalization, and impaired functional recovery.
Methods. For this review, a systematic literature search and analysis were conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol, which includes a clear step-by-step procedure for identification, screening, eligibility assessment, and inclusion of relevant data. Publications indexed in the PubMed and eLibrary databases from 2012 to 2025 were analyzed. A total of 51 studies were included in the final analysis, of which 21 met the inclusion criteria: studies assessing the impact of frailty on the incidence of postoperative complications, length of hospital stay, mortality rates, and the need for rehabilitation in patients undergoing minimally invasive surgical procedures. The selection of publications was performed independently by two reviewers, and any disagreements were resolved through discussion with a third expert. Data from the included studies were systematized according to key outcomes and methods used to assess frailty.
Results. A scoping review of the literature was conducted, summarizing data on surgical outcomes in frail patients undergoing minimally invasive procedures. The analysis confirms that patients with a high degree of frailty have a significantly increased risk of adverse outcomes, even in minimally invasive surgeries. However, modern frailty assessment tools allow for better risk prediction and adaptation of surgical strategies. While minimally invasive techniques demonstrate superior outcomes compared to open surgeries, they still require a personalized approach and enhanced perioperative monitoring.
Conclusion. This review highlights the need for routine frailty screening in clinical practice to improve the safety of surgical treatment in elderly patients and optimize perioperative management strategies.

About the Authors

A. I. Chernykh
State Budgetary Institution ‘Moscow Clinical Science and Research Centre 52
Russian Federation

Chernykh Anatoly Igorevich – surgeon, Candidate of Medical Sciences 

3 Pekhotnaya str., Moscow, 123182



V. I. Vtorenko
State Budgetary Institution ‘Moscow Clinical Science and Research Centre 52
Russian Federation

Vtorenko Vladimir Ivanovich – President, Doctor of Medical Sciences, Professor 

3 Pekhotnaya str., Moscow, 123182



S. E. Rodnikov
State Budgetary Institution ‘Moscow Clinical Science and Research Centre 52
Russian Federation

Rodnikov Sergey Evgenievich – Head of Surgical Department No. 1, Candidate of Medical Sciences 

3 Pekhotnaya str., Moscow, 123182



D. Yu. Komissarov
State Budgetary Institution ‘Moscow Clinical Science and Research Centre 52
Russian Federation

Komissarov Dmitry Yuryevich – Head of the endoscopic department, doctor of the highest qualification category 

3 Pekhotnaya str., Moscow, 123182



R. R. Mudarisov
State Budgetary Institution ‘Moscow Clinical Science and Research Centre 52
Russian Federation

Mudarisov Rinat Rifkatovich – Deputy Chief Physician for Surgical Care, Candidate of Medical Sciences, Associate Professor 

3 Pekhotnaya str., Moscow, 123182



References

1. Fried Linda P., Alan A. Cohen, Qian-Li Xue, Jeremy Walston, Karen Bandeen-Roche, and Ravi Varadhan. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nature Aging, 2021, № 1, рр. 36–46. https://doi.org/10.1038/s43587-020-00017-z

2. Komleva Yu. K., A. B. Salmina K. A. Shpiliukova N. I. Bondar Yu. A. Shpilyukova, and S. N. Illarioshkin. Frailty in modern geriatrics and neurology. Russian neurological journal, 2025, № 30, рр. 4–15. https://doi.org/10.30629/2658-7947-2025-30-1-4-15

3. Kuzmin I.V., Novitsky A.V., Nevirovich E.S., Tkachuk I.N., Kostenkov N.Yu. Selection of treatment methods for patients with large benign prostatic hyperplasia combined with senile asthenia syndrome. Contemporary Problems of Health Care and Medical Statistics, 2021, № 2, рp. 97–106. https://doi.org/10.24412/2312-2935-2021-2-97-107. (In Russ).

4. Tkacheva, O. N., N. K. Runikhina, Yu. V. Kotovskaya, S. R. Gilyarevsky, L. A. Aleksanyan, A. V. Rozanov, A. A. Pronchenko, et al. Clinical Guidelines for Perioperative Care of Older and Oldest-Old Patients Living with Frailty Undergoing Elective Surgery. Russian Journal of Geriatric Medicine, 2024, № 16, рр. 218–232. https://doi.org/10.37586/2686-8636-4-2023-218-232.

5. Baranchikov A.A., Gorelik S.G., Ishchenko K.A., Milyutina E.V., Gorbunova E.O. Analysis of the impact of preventive measures aimed at reducing the risk of developing geriatric syndromes after elective surgery. Contemporary Problems of Health Care and Medical Statistics, 2022, № 3, pp. 87–99. https://doi.org/10.24412/2312-2935-2022-3-87-100. (In Russ).

6. Hanna, Kamil, Michael Ditillo, and Bellal Joseph. The role of frailty and prehabilitation in surgery. Current Opinion in Critical Care, 2019, № 25, рр. 717–722. https://doi.org/10.1097/MCC.0000000000000669

7. Smirnov A.V., Stankevich V.R., Danilina E.S., Sychev V.I., Voronets E.M., Sharobaro V.I., Solovyev N.A., Ivanov Y.V., and Khabazov R.I.. Bariatric surgery in elderly patients. Journal of Clinical Practice, 2024, № 15, рр. 7–17. https://doi.org/10.17816/clinpract642653

8. Kołodziejska Katarzyna, Tylec P., Jakub Droś, Artur Kacprzyk, Wojciech Kula, Maciej Matyja, Michał Pędziwiatr, and Mateusz Rubinkiewicz. Modified Frailty Index and Brief Geriatric Assessment do not predict prolonged hospitalization in elderly patients undergoing appendectomy due to Acute Appendicitis. Polish Journal of Surgery, 2022, № 95, рр. 34–39. https://doi.org/10.5604/01.3001.0016.0663

9. Konstantinidis Ioannis T., Aaron Lewis, Byrne Lee, Susanne G. Warner, Yanghee Woo, Gagandeep Singh, Yuman Fong, and Laleh G. Melstrom. Minimally invasive distal pancreatectomy: greatest benefit for the frail. Surgical Endoscopy, 2017, № 31(5), рр. 234–5240. https://doi.org/10.1007/s00464-017-5593-y

10. Lo Brian D., Ira L. Leeds, Margaret H. Sundel, Susan Gearhart, Gabriela R.C. Nisly, Bashar Safar, Chady Atallah, and Sandy H. Fang. Frailer Patients Undergoing Robotic Colectomies for Colon Cancer Experience Increased Complication Rates Compared With Open or Laparoscopic Approaches. Diseases of the Colon & Rectum, 2020, № 63, рр. 588–597. https://doi.org/10.1097/DCR.0000000000001598

11. Mastalerz Kinga, Jakub Kenig, Urszula Olszewska, and Cyprian Michalik. The Surgical Apgar Score and frailty as outcome predictors in short- and long-term evaluation of fit and frail older patients undergoing elective laparoscopic cholecystectomy - a prospective cohort study. Videosurgery and Other Miniinvasive Techniques, 2018, №13(3), рр. 350–357. https://doi.org/10.5114/wiitm.2018.75878

12. Zakhary,Bishoy, Bruno C Coimbra, Junsik Kwon, Timothy Allison-Aipa, Matthew Firek, and Raul Coimbra. Impact of Procedure Risk vs Frailty on Outcomes of Elderly Patients Undergoing Emergency General Surgery: Results of a National Analysis. Journal of the American College of Surgeons, 2024, № 239, рр. 211–222. https://doi.org/10.1097/XCS.0000000000001079

13. Al-Husinat, Lou’i, Saif Azzam, Sarah Al Sharie, Laith Al Hseinat, Mohammad Araydah, Zaid Al Modanat, Ala Riyad Balawi, et al. Impact of the American Society of Anesthesiologists (ASA) classification on hip fracture surgery outcomes: insights from a retrospective analysis. BMC Anesthesiology, 2024, № 24, P.271. https://doi.org/10.1186/s12871-024-02660-0

14. Mosquera Catalina, Konstantinos Spaniolas, and Timothy L Fitzgerald. Impact of frailty on approach to colonic resection: Laparoscopy vs open surgery. World Journal of Gastroenterology, 2016, № 22, P. 9544. https://doi.org/10.3748/wjg.v22.i43.9544

15. Fagenson, Alexander M., Benjamin D. Powers, Konstantinos A. Zorbas, Sunil Karhadkar, Andreas Karachristos, Antonio Di Carlo, and Kwan N. Lau. Frailty Predicts Morbidity and Mortality After Laparoscopic Cholecystectomy for Acute Cholecystitis: An ACS-NSQIP Cohort Analysis. Journal of Gastrointestinal Surgery, 2021, № 25, рр. 932–940. https://doi.org/10.1007/s11605-020-04570-1

16. O’Caoimh, Rónán, Duygu Sezgin, Mark R O’Donovan, D William Molloy, Andrew Clegg, Kenneth Rockwood, and Aaron Liew. Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies. Age and Ageing, 2021, № 50, рр. 96–104. https://doi.org/10.1093/ageing/afaa219

17. Snitkjær, Christian, Lasse Rehné Jensen, Liv Í Soylu, Camilla Hauge, Madeline Kvist, Thomas K Jensen, Dunja Kokotovic, and Jakob Burcharth. Impact of clinical frailty on surgical and non-surgical complications after major emergency abdominal surgery. BJS Open, 2024, № 8, zrae039. https://doi.org/10.1093/bjsopen/zrae039

18. Tanaka, Tsuyoshi, Koichi Suda, Kazuki Inaba, Yusuke Umeki, Ai Gotoh, Yoshinori Ishida, and Ichiro Uyama. Impact of Frailty on Postoperative Outcomes for Laparoscopic Gastrectomy in Patients Older than 80 Years. Annals of Surgical Oncology, 2019, № 26, рр. 4016–4026. https://doi.org/10.1245/s10434-019-07640-0

19. Kim, Dae Hyun, and Kenneth Rockwood. Frailty in Older Adults. Edited by C. Corey Hardin. New England Journal of Medicine, 2024, № 391, рр. 538–548. https://doi.org/10.1056/NEJMra2301292

20. Arksey, Hilary, and Lisa O’Malley. Scoping studies: towards a methodological framework. International Journal of Social Research Methodology, 2005, № 8, рр. 19–32. https://doi.org/10.1080/1364557032000119616

21. Peters, Micah D.J., Christina M. Godfrey, Hanan Khalil, Patricia McInerney, Deborah Parker, and Cassia Baldini Soares. Guidance for conducting systematic scoping reviews. International Journal of Evidence-Based Healthcare, 2015, № 13, рр. 141–146. https://doi.org/10.1097/XEB.0000000000000050

22. Tricco, Andrea C., Erin Lillie, Wasifa Zarin, Kelly K. O’Brien, Heather Colquhoun, Danielle Levac, David Moher, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, 2018, № 169, рр. 467–473. https://doi.org/10.7326/M18-0850

23. Ho, Be, Aaron Lewis, and I. Benjamin Paz. Laparoscopy Can Safely Be Performed in Frail Patients Undergoing Colon Resection for Cancer. The American Surgeon, 2017, № 83, рр. 1179–1183.

24. Paiella, Salvatore, Matteo De Pastena, Alessandro Esposito, Erica Secchettin, Luca Casetti, Giuseppe Malleo, Greta Montagnini, et al. Modified Frailty Index to Assess Risk in Elderly Patients Undergoing Distal Pancreatectomy: A Retrospective Single‐Center Study. World Journal of Surgery, 2022, № 46, рр. 891–900. https://doi.org/10.1007/s00268-021-06436-2

25. Shinall, Myrick C., Shipra Arya, Ada Youk, Patrick Varley, Rupen Shah, Nader N. Massarweh, Paula K. Shireman, et al. Association of Preoperative Patient Frailty and Operative Stress With Postoperative Mortality. JAMA Surgery, 2020, № 155, e194620. https://doi.org/10.1001/jamasurg.2019.4620

26. Zhou, Yang, Yongxiang Ge, Jian Liu, Weijian Shen, Hailiang Gu, and Guochang Cheng. Modified Frailty Index and Albumin-Fibrinogen Ratio Predicts Postoperative Seroma After Laparoscopic TAPP. Clinical Interventions in Aging, 2023, №18, рр. 1397–1403. https://doi.org/10.2147/CIA.S418338

27. Tartaglia, Dario, Federico Coccolini, Camilla Cremonini, Silvia Strambi, Serena Musetti, Enrico Cicuttin, Armando Di Dato, et al. Laparoscopic cholecystectomy for acute calculous cholecystitis in elderly. More complex but equally safe and effective. Annali Italiani Di Chirurgia, 2022, № 93, рр. 550–556.

28. Lu, Jun, Hua-Long Zheng, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jian-Xian Lin, Qi-Yue Chen, et al. High preoperative modified frailty index has a negative impact on short- and long-term outcomes of octogenarians with gastric cancer after laparoscopic gastrectomy. Surgical Endoscopy, 2018, № 32, рр. 2193–2200. https://doi.org/10.1007/s00464-018-6085-4

29. Mrdutt, Mary M., Harry T. Papaconstantinou, Bobby D. Robinson, Erin T. Bird, and Claire L. Isbell. Preoperative Frailty and Surgical Outcomes Across Diverse Surgical Subspecialties in a Large Health Care System. Journal of the American College of Surgeons, 2019, № 228, рр. 482–490. https://doi.org/10.1016/j.jamcollsurg.2018.12.036

30. Hossain, Monowar, D. Yu, B. Bikdeli, and S. Yu. Sarcopenia and Adverse Post-Surgical Outcomes in Geriatric Patients: A Scoping Review. The Journal of Frailty & Aging, 2021, № 10, рр. 63–69. https://doi.org/10.14283/jfa.2020.27

31. Lo, Brian D., Ira L. Leeds, Margaret H. Sundel, Susan Gearhart, Gabriela R.C. Nisly, Bashar Safar, Chady Atallah, and Sandy H. Fang. Frailer Patients Undergoing Robotic Colectomies for Colon Cancer Experience Increased Complication Rates Compared With Open or Laparoscopic Approaches. Diseases of the Colon & Rectum, 2020, № 63, рр. 588–597. https://doi.org/10.1097/DCR.0000000000001598

32. Lu, Chien-Chang, Chi-Tung Lu, Kai-Yen Chang, Wang Chun-Li, and Chien-Ying Wu. Robot-assisted vs. laparoscopic right hemicolectomy in octogenarians and nonagenarians: an analysis of the US nationwide inpatient sample 2005–2018. Aging Clinical and Experimental Research, 2024, №36, Р.193. https://doi.org/10.1007/s40520-024-02833-4

33. Collins, Micaela L., Shale J. Mack, Brian M. Till, Gregory L. Whitehorn, Christina Tofani, Karen Chojnacki, Tyler Grenda, Nathaniel R. Evans, and Olugbenga T. Okusanya. Defining risk factors for mortality after emergent hiatal hernia repair in the era of minimally invasive surgery. The American Journal of Surgery, 2023, № 225, рр. 1056–1061. https://doi.org/10.1016/j.amjsurg.2023.01.012

34. Rangel, Erika L., Arturo J. Rios-Diaz, Jennifer W. Uyeda, Manuel Castillo-Angeles, Zara Cooper, Olubode A. Olufajo, Ali Salim, and Aaron D. Sodickson. Sarcopenia increases risk of long-term mortality in elderly patients undergoing emergency abdominal surgery. Journal of Trauma and Acute Care Surgery, 2017, № 83, рр. 1179–1186. https://doi.org/10.1097/TA.0000000000001657

35. Osei‐Bordom, D., L. Hall, J. Hodson, K. Joshi, L. Austen, D. Bartlett, J. Isaac, et al. Impact of Frailty on Short‐Term Outcomes After Laparoscopic and Open Hepatectomy. World Journal of Surgery, 2022, № 46, рр. 2444–2453. https://doi.org/10.1007/s00268-022-06648-0

36. Fransvea, Pietro, Gianluca Costa, Luca Lepre, Mauro Podda, Alessio Giordano, Giovanni Bellanova, Ferdinando Agresta, Pierluigi Marini, and Gabriele Sganga. Laparoscopic Repair of Perforated Peptic Ulcer in the Elderly: An Interim Analysis of the FRAILESEL Italian Multicenter Prospective Cohort Study. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 2021, № 31, рр. 2–7. https://doi.org/10.1097/SLE.0000000000000826

37. Ramsay, Euan A., Ben Carter, Roy L. Soiza, Siobhan Duffy, Susan J. Moug, and Phyo K. Myint. Frailty is associated with increased waiting time for relevant process-of-care measures; findings from the Emergency Laparoscopic and Laparotomy Scottish audit (ELLSA). British Journal of Surgery, 2022, № 109, рр. 172–175. https://doi.org/10.1093/bjs/znab371

38. Xu, Thomas Q., Jesse Maguire, and Jon Gould. The impact of frailty on outcomes following laparoscopic repair of ‘giant’ paraesophageal hernias. Surgical Endoscopy, 2023, № 37, рр. 6532–6537. https://doi.org/10.1007/s00464-023-10163-1


Review

For citations:


Chernykh A.I., Vtorenko V.I., Rodnikov S.E., Komissarov D.Yu., Mudarisov R.R. The impact of frailty on outcomes of minimally invasive laparoscopic surgery in elderly patients: a scoping review. Moscow Surgical Journal. 2025;(4):179-194. (In Russ.) https://doi.org/10.17238/2072-3180-2025-4-179-194

Views: 102

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-3180 (Print)