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Low-temperature Argon Plasma: from the Biophysical Foundations for practical application in clinical medicine

https://doi.org/10.17238/2072-3180-2025-3-178-189

Abstract

Introduction. Low-temperature argon plasma (LTAP) is increasingly being used in medicine due to its antimicrobial, anti-inflammatory, and regenerative properties. Objective. To compare the energy parameters of ultraviolet radiation emitted by the "Plazmoran" and "PLAZON" devices to evaluate their effectiveness in clinical practice.
Materials and Methods. The study was conducted using two devices: – "Plazmoran" (operates on argon) – "PLAZON" (uses air). The energy illumination of UV radiation was measured at distances of 10, 15, and 20 cm. For "Plazmoran," mode B2 was used; for "PLAZON," the maximum mode was applied.
Results. "Plazmoran" demonstrated 5 times higher illumination in the UV-C range compared to "PLAZON." This is attributed to the use of argon, which ensures stable recombinant radiation. With increasing distance, the effectiveness decreases due to the absorption of UV radiation by oxygen in the air. Clinical data confirm the efficacy of LTAP in treating wounds, burns, dermatological diseases, and blast injuries in children. The application of plasma promotes faster wound healing, reduces inflammation, and activates tissue regeneration.
Conclusion. The "Plazmoran" device has higher energy characteristics and more stable effects, making it preferable for clinical use. The use of argon eliminates unwanted chemical reactions and enhances therapeutic efficacy. The obtained results confirm the promising prospects for further integration of LTAP technologies into medical practice.

About the Authors

A. B. Zemlyanoi
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation ; Department of Trauma Surgery, Federal State Budgetary Institution Higher Education Rosbiotech, Medical Institute for Continuous Education, Ministry of Science and Higher Education of the Russian Federation
Russian Federation

Zemlyanoi Alexander Borisovich – Doctor of Medical Sciences, Professor, Leading Researcher

1, territory 3, Novy Settlement, Krasnogorsk, Moscow Region, 143420



M. A. Evseev
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Evseev Maxim Alexandrovich – Doctor of Medical Sciences, Professor, Deputy Head of Scientific Work  

1, territory 3, Novy Settlement, Krasnogorsk, Moscow Region, 143420



P. S. Markevich
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Markevich Pavel Sergeyevich – Candidate of Medical Sciences, Lieutenant Colonel of the Medical Service, Head of the 63rd Department of Purulent Surgery

1, territory 3, Novy Settlement, Krasnogorsk, Moscow Region, 143420



A. V. Filippov
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Filippov Alexander Viktorovich – Candidate of Medical Sciences, Lieutenant Colonel of the Medical Service, Chief Surgeon

1, territory 3, Novy Settlement, Krasnogorsk, Moscow Region, 143420



R. N. Dolgikh
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Dolgikh Ruslan Nikolaevich – Candidate of Medical Sciences, Colonel of the Medical Service, Surgeon

1, territory 3, Novy Settlement, Krasnogorsk, Moscow Region, 143420



Yu. A. Tyukalov
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Tyukalov Yuri Alexandrovich – Surgeon of the 12th Department of Abdominal Surgery

1, territory 3, Novy Settlement, Krasnogorsk, Moscow Region, 143420



R. T. Nalbandian
Municipal Healthcare Institution "Research Institute of Emergency Pediatric Surgery and Traumatology – Dr. Roche's Clinic"
Russian Federation

Nalbandian Ruben Tigranovich – Candidate of Medical Sciences, Head of the Department of Wounds and Wound Infections

22 Bolshaya Polyanka str., Moscow, 119180 



T. A. Zelenina
Department of Therapy for Physicians' Training, Federal State Budgetary Institution Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation
Russian Federation

Zelenina Tatiana Aleksandrovna – Candidate of Medical Sciences, Associate Professor, endocrinologist, Senior lecturer at the TUV-1 Department with a course in endocrinology



A. A. Gromova
Department of Therapy for Physicians' Training, Federal State Budgetary Institution Military Medical Academy named after S.M. Kirov, Ministry of Defense of the Russian Federation
Russian Federation

Gromova Anastasia Alexandrovna – Surgeon 

22 Bolshaya Polyanka str., Moscow, 119180 



N. G. Gerasimov
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Gerasimov Nikita Gennadievich – Major of the Medical Service, Surgeon of the 63rd Department of Purulent Surgery

1, territory 3, Novy settlement, Krasnogorsk, Moscow Region, 143420 



I. A. Pesterev
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Pesterev Ivan Aleksandrovich – Traumatologist of the 63rd Department of Purulent Surgery

1, territory 3, Novy settlement, Krasnogorsk, Moscow Region, 143420 



D. S. Koretsky
Federal State Budgetary Institution National Medical Research Center of High Technologies named after A.A. Vishnevsky, Ministry of Defense of the Russian Federation
Russian Federation

Koretsky Danil Sergeevich – Traumatologist of the 63rd Department of Purulent Surgery

1, territory 3, Novy settlement, Krasnogorsk, Moscow Region, 143420 



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For citations:


Zemlyanoi A.B., Evseev M.A., Markevich P.S., Filippov A.V., Dolgikh R.N., Tyukalov Yu.A., Nalbandian R.T., Zelenina T.A., Gromova A.A., Gerasimov N.G., Pesterev I.A., Koretsky D.S. Low-temperature Argon Plasma: from the Biophysical Foundations for practical application in clinical medicine. Moscow Surgical Journal. 2025;(3):178-189. (In Russ.) https://doi.org/10.17238/2072-3180-2025-3-178-189

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