The significance of markers of systemic inflammation in conciliatory recommendations for the treatment of surgical diseases
A. M. Karsanov,
M. D. Lagkuev,
A. S. Asatryan,
D. A. Khubulova,
M. V. Pliev,
A. M. Lyadnov,
V. R. Dzutsev,
S. S. Maskin https://doi.org/10.17238/2072-3180-2024-4-253-262
Abstract
Introduction. The need for highly sensitive and highly specific markers of systemic inflammation (MI) in most emergency surgical diseases remains an urgent scientific and clinical task.
Results. The article is devoted to the description of the main characteristics of the most accessible MI used in abdominal diseases. Thus, in acute appendicitis, it is recommended to assess the level of C-reactive protein and procalcitonin not only for primary diagnostics, but also as a differential criterion between uncomplicated and complicated forms of the disease. The use of MI in patients with suspected acute cholecystitis is even more important than in other acute abdominal diseases, since early stratification of cohorts by disease severity is crucial for the timing and extent of surgical treatment in this patient population. The presence and varying severity of the aseptic inflammation phase, and especially the development of infected acute pancreatitis, leave no other options than to monitor not only vital functions in patients, but also the dynamics of MI concentration. Non-specificity of symptoms, wide variability of clinical and morphological manifestations of intra-abdominal inflammation formed the basis for recommendations on mandatory determination of the level of C-reactive protein in the blood serum of patients with acute diverticulitis.
Conclusions. Effective MI should be used in emergency abdominal surgery not only for early verification of the inflammatory genesis of the patient's painful condition, selection of the optimal therapeutic component, but also for prognosis, and especially for monitoring the course of the disease.
About the Authors
A. M. Karsanov
North Ossetian State Medical Academy
Russian Federation
Russian Federation
Karsanov Alan Mukharbekovich – Candidate of Medical Sciences, Associate Professor of the Department of Surgery № 3,
362025, st. Pushkinskaya, 40, Vladikavkaz, North Ossetia-Alania state
M. D. Lagkuev
Republican Clinical Hospital
Russian Federation
Russian Federation
Lagkuev Magomet Dzhabrailovich – Deputy chief physician,
362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania
A. S. Asatryan
Republican Clinical Hospital
Russian Federation
Russian Federation
Asatryan Arshavir Samvelovich – Head of the Department of Coloproctology,
362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania
D. A. Khubulova
North Ossetian State Medical Academy
Russian Federation
Russian Federation
Khubulova Dina Arshakovna – Candidate of Medical Sciences, Associate Professor of the Department of Surgery № 3,
362025, st. Pushkinskaya, 40, Vladikavkaz, North Ossetia-Alania state
M. V. Pliev
Republican Clinical Hospital
Russian Federation
Russian Federation
Pliev Marat Valerievich – Head of the Combined Trauma Department,
362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania
A. M. Lyadnov
Republican Clinical Hospital
Russian Federation
Russian Federation
Lyadnov Artur Maranjvich – Surgeon,
362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania
V. R. Dzutsev
Republican Clinical Hospital
Russian Federation
Russian Federation
Dzutsev Vitaliy Ruslanovich – Head of the Department of vascular surgery,
362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania
S. S. Maskin
Volgograd State Medical University
Russian Federation
Russian Federation
Maskin Sergey Sergeevich – Doctor of Medical Sciences, Professor, head of the Department of hospital surgery,
400131, Pavshikh Bortsov Sq., Volgograd
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For citations:
Karsanov A.M., Lagkuev M.D., Asatryan A.S., Khubulova D.A., Pliev M.V., Lyadnov A.M., Dzutsev V.R., Maskin S.S. The significance of markers of systemic inflammation in conciliatory recommendations for the treatment of surgical diseases. Moscow Surgical Journal. 2024;(4):253-262. (In Russ.) https://doi.org/10.17238/2072-3180-2024-4-253-262
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