Preview

Moscow Surgical Journal

Advanced search

Modern approaches to treatment of recurrent laryngeal nerve injuries after thyroidectomy

https://doi.org/10.17238/2072-3180-2025-3-228-237

Abstract

Introduction. Intraoperative neuromonitoring in modern surgical intervention on the thyroid gland, there is a certain risk of postoperative complications. Intraoperative injury to the recurrent laryngeal nerve (RLN) continues to be one of the most common and leads to a decrease in the quality of life of patients and loss of professional activity.
The purpose of the study. To study modern conservative and surgical methods of treating intraoperative injury to the recurrent laryngeal nerve in surgical treatment of thyroid diseases.
Materials and methods of research. A review of data in PubMed, ScienceDirect, eLIBRARY was performed. Exclusion criteria for the analysis: descriptions of individual clinical cases; books and documents. Of the initially identified 108 sources, 46 were included in the review.
Treatment results. The highest efficiency among the options for drug therapy of intraoperative injury of the RLN is demonstrated by the administration of neuromedin, proserin, nimodipine and dexamethasone. Among the methods of surgical treatment of RLN injuries, microsurgical plastic surgery of damaged vocal cords, percutaneous or endoscopic injection laryngoplasty and medializing thyroplasty are used.
Conclusion. Drug treatment of RLN injuries is effective in 65-88% of cases, surgical treatment – in 78–94 %. Conservative methods of treatment require long-term use, which leads to a gradual restoration of the RLN function. Despite the high efficiency of surgical methods, there is a high risk of complications in the postoperative period, which requires careful selection of patients and an assessment of the degree of risk of surgical intervention and its absence.

About the Authors

A. Yu. Laptiyova
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko ; Clinical Hospital “RZhD-Medicine” in Voronezh
Russian Federation

Laptiyova Anastasia Yuryevna – MD, PhD, oncologist, surgeon

394036, Voronezh, st. Studencheskaya, 10,



M. B. Remezov
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko
Russian Federation

Remezov Mikhail Borisovich – 5th-year student, Faculty of Pediatrics  

394036, Voronezh, st. Studencheskaya, 10,



A. A. Glukhov
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko
Russian Federation

Glukhov Aleksandr Anatolyevich – MD, Professor, Head of the Department 

394036, Voronezh, st. Studencheskaya, 10,



V. V. Novomlinsky
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko ; Clinical Hospital “RZhD-Medicine” in Voronezh
Russian Federation

Novomlinsky Vladislav Valerievich – MD, PhD, Deputy Chief Physician for Surgical Care

394036, Voronezh, st. Studencheskaya, 10,



D. Yu. Kharitonova
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko
Russian Federation

Kharitonova Darya Yuryevna – 6th-year student, Faculty of General Medicine

394036, Voronezh, st. Studencheskaya, 10,



A. P. Ostroushko
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko ; Clinical Hospital “RZhD-Medicine” in Voronezh
Russian Federation

Ostroushko Anton Petrovich – MD, PhD, oncologist, surgeon, Associate Professor 

394036, Voronezh, st. Studencheskaya, 10,



S. S. Popov
Department of General and Outpatient Surgery, Voronezh State Medical University named after N.N. Burdenko ; Voronezh City Clinical Hospital of Emergency Medical Care No. 8
Russian Federation

Popov Stanislav Sergeevich – MD, PhD; Chief Physician, Associate Professor 

394036, Voronezh, st. Studencheskaya, 10



References

1. Alqahtani S.M., Al-sohabi H.R., Rayzah M.F., Alatawi A.S., AlFattani A.A., Alalawi Y.S. Recurrent laryngeal nerve injury after thyroidectomy: A national study from Saudi Arabia. Saudi Medical Journal, 2023, № 1, pp. 80–82. https://doi.org/10.15537/smj.2023.44.1.20220710

2. Aygun N., Kostek M., Unlu M.T., Isgor A., Uludag M. Study of paralysis of recurrent laryngeal nerve after thyroidectomy. Frontiers in Surgery, 2022, pp. 1–11. https://doi.org/10.53350/pjmhs22167985

3. Sigal Z.M., Surnina O.V. Determination of pulsed and non-pulse optical density in thyroid cancer, adenoma and cyst. Volga Region Oncological Bulletin, 2018, № 1, pp. 5. (In Russ.)

4. Lukyanov S.A., Sergiyko S.V., Titov S.E., Veryaskina Yu.A., Vazhenin A.V. Molecular genetic markers of papillary thyroid cancer aggressiveness. Tavricheskiy Mediko-Biologicheskiy Vestnik, 2019, № 3, pp. 16. https://doi.org/10.37279/2070-8092-2020-23-2-92-99 (in Russ.)

5. Mohammad R., Huh G., Cha W., Jeong W.J. Recurrent laryngeal nerve paralysis following thyroidectomy: analysis of factors affecting nerve recovery. Laryngoscope, 2022, № 8, pp. 1–5. https://doi.org/10.1002/lary.30024

6. Timofeeva L.A., Aleshina T.N., Baranova M.E., Yusova M.A., Nikolaeva N.N. Informativeness of sonoelastography in the differential diagnosis of follicular thyroid cancer. Acta Medica Eurasica, 2021, № 4, pp. 73. https://doi.org/10.47026/2413-4864-2021-4-73-78 (in Russ.)

7. Karpathiotakis M., D'Orazi V., Ortensi A., Biancucci A., Melcarne R., Borcea M.C., Scorziello C., Tartaglia F. Intraoperative Neuromonitoring and Optical Magnification in the Prevention of Recurrent Laryngeal Nerve Injuries during Total Thyroidectomy. Medicina, 2022, № 11, pp. 1–9. https://doi.org/10.3390/medicina58111560

8. Santosh Uttarkar Panduranga Rao, Sumanth K. R. Total thyroidectomy using intracapsular dissection: the technique, complications, and surgical outcomes. The Egyptian Journal of Otolaryngology, 2022, № 1, pp. 1–3. https://doi.org/10.1186/s43163-022-00256-4

9. Kharnas S.S., Ippolitov L.I., Nasimov B.T., Vychuzhanin D.V. Prevention of damage to the recurrent laryngeal nerves during thyroid surgery. Vrach, 2015, № 5, pp. 22–23. (In Russ.)

10. Malyuga V.Yu., Kuprin A.A. Extralaryngeal variants of the location of the recurrent laryngeal nerve. Clinical observation in thyroid surgery. Endocrine surgery, 2017, № 3, pp. 147, 152–154. https://doi.org/10.14341/serg20173146-156 (in Russ.)

11. Sleptsov I.V., Chernikov R.A., Sablin I.V., Pushkaruk A.A., Timofeeva N.I. Medial thyroidectomy – results of the first 77 operations. Endocrine surgery, 2022, № 2, pp. 2, 3, 6–9. https://doi.org/10.14341/serg12718 (in Russ.)

12. Peng L., Qing-Zhuang L., Dong-Lai W., Bin H., Xin Y., Wei W., Feng-Yu C. The transcutaneous electromyography recording method for intraoperative neuromonitoring of recurrent laryngeal nerve during minimally invasive parathyroidectomy. Scientific Reports, 2020, № 1, p. 6 https://doi.org/10.1038/s41598-020-64675-0

13. Lee Y.Ki., Yang W., Ghedia R., Kim D. Non-recurrent laryngeal nerve and aberrant subclavian artery in thyroidectomy. BMJ Case Reports, 2022, № 8, pp. 1–2. https://doi.org/10.1136/bcr-2022-251374

14. Spartalis E., Giannakodimos A., Giannakodimos I., Ziogou A., Papasilekas T., Patelis N., Schizas D., Troupis T. The role of LigaSure™ and Harmonic Scalpel in the preservation of recurrent laryngeal nerve during thyroidectomy. Annals of The Royal College of Surgeons of England, 2021, № 5, pp. 1–5. https://doi.org/10.1308/rcsann.2021.0125

15. Fagni N., Gelati G., Veltro C., Paternostro F. Intraoperative monitoring of the recurrent laryngeal nerve in thyroid gland surgery. Infermieristica journal, 2023, № 1, pp. 65–69. https://doi.org/10.36253/if-1876

16. Vetshev P.S., Yankin P.L., Zhivotov V.A., Poddubny E.I., Prokhorov V.D. Results of using intraoperative neuromonitoring of the recurrent laryngeal nerves in thyroid surgery. Bulletin of the National Medical and Surgical Center named after N.I. Pirogov, 2018, № 4, pp. 41–47. https://doi.org/10.25881/BPNMSC.2018.90.41.007 (in Russ.)

17. Yudin M.Yu., Klimashevich A.V., Feoktistov Ya.E., Sergatsky K.I., Kozhunov A.A. Comparison of satisfaction with the voice of patients operated on the thyroid gland for benign diseases using various methods of visualization of nerve structures. News of higher educational institutions. Volga region. Medical sciences, 2023, № 1, pp. 26, 33–34. https://doi.org/10.21685/2072-3032-2023-1-3 (in Russ.)

18. Billah M., Durrani S. N., Baloch A.H., Khan A., Nadeem M., Asghar F. Study of Paralysis of Recurrent Laryngeal Nerve after Thyroidectomy. Pakistan Journal of Medical & Health Sciences, 2022, № 7, 297 p. https://doi.org/10.53350/pjmhs22167985

19. Krishnan P. B., Santosh M. P. An atypical bilateral trifurcation of recurrent laryngeal nerve. BMC Surgery, 2022, № 1, pp. 2–3. https://doi.org/10.1186/s12893-022-01624-w

20. Krasilnikov D.M., Mirgasimova D.M., Matveev V.Yu., Zakharova A.V., Korneeva A.V., Netfullov R.Z. Surgical treatment of patients with benign thyroid diseases in their retrosternal location. Modern problems of science and education, 2024, № 1, pp. 2. https://doi.org/10.17513/spno.33273 (in Russ.)

21. Belokonev V.I., Pushkin S.Yu., Kovaleva Z.V., Chemidronov S.N., Bezzubov A.R., Galstyan N.E. Ways to master a safe thyroidectomy technique for diseases of the thyroid and parathyroid glands. Surgery. Journal N.I. Pirogov, 2022, № 6, pp. 63, 66–69. https://doi.org/10.17116/hirurgia202206162 (in Russ.)

22. Yudin M.Yu., Klimashevich A.V. The influence of high-quality visualization of the external branch of the superior laryngeal nerve during thyroid surgery using neuromonitoring on the immediate and long-term treatment results. Actual problems of medicine, 2022, № 2, pp. 220–226. https://doi.org/10.52575/2687-0940-2022-45-2-217-232 (in Russ.)

23. Wojtczak B., Marciniak D., Kaliszewski K., Sutkowski K., Głód M., Rudnicki J., Bolanowski M., Barczyński M. Proving the Superiority of Intraoperative Recurrent Laryngeal Nerve Monitoring over Visualization Alone during Thyroidectomy. Biomedicines, 2023, № 3, pp. 3, 13–15. https://doi.org/10.3390/biomedicines11030880

24. Shilenkova V.V. On voice rehabilitation in unilateral vocal fold paresis. Bulletin of Otorhinolaryngology, 2016, № 5, pp. 68–69, 71. https://doi.org/10.17116/otorino201681567-72 (in Russ.)

25. Krivopalov A.A., Braiko I.I., Shamkina P.A., Kanina A.D. Surgical treatment of bilateral paralytic stenosis of the larynx. Russian Otolaryngology, 2019, № 3, pp. 80. https://doi.org/10.18692/1810-4800-2019-3-79-86 (in Russ.)

26. Choynzonov E.L., Balatskaya L.N., Chizhevskaya S.Yu., Cheremisina O.V., Krasavina E.A., Zhuykova L.D. Voice rehabilitation of patients with unilateral laryngeal paresis after surgical treatment of thyroid cancer. Problems of Endocrinology, 2018, № 6, pp. 357–359. https://dx.doi.org/10.14341/probl9648 (in Russ.)

27. Schietroma M., Cecilia E.M., Carlei F., Sista F., De Santis G., Lancione L., Amicucci G. Dexamethasone for the prevention of recurrent laryngeal nerve palsy and other complications after thyroid surgery: a randomized double-blind placebo-controlled trial. JAMA Otolaryngol Head Neck Surg., 2013, № 5, pp. 472–476. https://doi.org/10.1001/jamaoto.2013.2821

28. Kuznetsova T.A., Morozova E.V., Krivomazov A.Yu., Syromyatnikov E.A., Shkileva I.Yu., Fetisova V.I., Shelyakina E.V., Ruzhitskaya L.V., Kasyanov B.V., Al-Kanani E. Retrospective analysis of surgical treatment of diseases of the thyroid and parathyroid glands. Medical sciences, 2017, № 5, pp. 635. (In Russ.)


Review

For citations:


Laptiyova A.Yu., Remezov M.B., Glukhov A.A., Novomlinsky V.V., Kharitonova D.Yu., Ostroushko A.P., Popov S.S. Modern approaches to treatment of recurrent laryngeal nerve injuries after thyroidectomy. Moscow Surgical Journal. 2025;(3):228-237. (In Russ.) https://doi.org/10.17238/2072-3180-2025-3-228-237

Views: 16


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-3180 (Print)