MORPHOLOGICAL STUDY OF ATROPHIC GASTRITIS ACCORDING TO THE CLASSIFICATION BY KIMURA-TAKEMOTO

Abstract

Due to the need of more sensitive methods for the morphological detection of precancerous changes in the gastric mucosa (coolant) with atrophic gastritis, the research goal was to study the prevalence of precancerous changes in the coolant in atrophic gastritis as part of a new morphological modifi ation of the Kimura-Takemoto classifi ation. We examined 169 patients selected by Kimura-Takemoto endoscopic criteria. There were 58 men (34%) and 111 women (66%). The average age was 66.44 ± 10.22 years. The biopsy was taken according to the protoсol from each site indicated by the boundaries of the atrophy C1, C2, C3, O1, O2, O3. The histology results were interpreted according to the visual-analogue scale of the Sydney system. Among 169 people, six patients had high-grade dysplasia. These patients did not show a strong correlation with severe intestinal metaplasia (r = 0.53, p> 0.05). In two patients with severe dysplasia out of six, intestinal metaplasia was not detected at all. Severe dysplasia was found in three patients (51, 70 and 76 years) with verifi d gastric cancer. These patients were fi st approached and were clinically diagnosed with late cancer. Th ee more patients with verifi d diffuse coolant atrophy died in the near future from cardiovascular diseases. Their age, at the time of detection of atrophic gastritis with severe dysplasia was: 69, 87 and 79 years. The effectiveness of research methodology for the morphological diagnosis of precancerous changes in coolant biopsy specimens in atrophic gastritis in accordance with the Kimura-Takemoto endoscopic classifi ation was proven.