Surgical site infections after lung resection
A. M. Vdovin,
A. V. Smolkina,
E. A. Toneev,
R. F. Shagdaleev,
E. A. Keshyan,
N. I. Belonogov,
A. B. Guseynov https://doi.org/10.17238/2072-3180-2025-2-88-96
Abstract
Introduction. To identify prognostic indicators associated with the development of surgical site infections (SSIs) following elective thoracotomy.
Materials and methods. The study was conducted at the Thoracic Oncology Surgery Department of the State Healthcare Institution of Ulyanovsk Regional Cancer Center. The analysis included patients who underwent lobectomy or atypical resection between January 1, 2021, and December 31, 2023 (Database RU 2024622259 dated May 24, 2024). A total of 468 patients were included, of whom 32 (6,8 %) developed SSIs.
Results. The incidence of SSIs was 32/468 (6,8 %). Univariate analysis revealed statistically significant predictors of SSI development: age (p = 0,022), presence of diabetes mellitus (p < 0,001) and obesity (p = 0,043), the extent of surgical intervention (p = 0.003) and its duration (p < 0.001), the stage of COPD (p = 0,043), intraoperative blood loss (p < 0.001), and postoperative air leakage (p < 0,001). Multivariate analysis identified statistically significant indicators: the presence of diabetes mellitus (OR 7,286; 95 % CI 3,083–17,219; p < 0,001), surgery duration (OR 1.013; 95 % CI 1.004–1.023; p = 0.007), volume of blood loss (OR 1,004; 95 % CI 1,001–1,007; p = 0,007), and prolonged air leakage (OR 4,444; 95 % CI 1,677–11,775; p = 0,003).
Conclusion. The incidence of SSIs following surgical treatment for lung diseases was 32 cases (6,8 %), of which 59,4 % corresponded to grade 2 on the Southampton scale.
About the Authors
A. M. Vdovin
City Clinical Hospital No. 67 named after L.A. Vorokhobov, Department of Healthcare of Moscow;
Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University
Russian Federation
Russian Federation
Vdovin Alexey Mikhailovich – trauma and orthopedic surgeon of the emergency traumatology department, State Budgetary Healthcare Institution of the City of Moscow; postgraduate student of the department of general and operative surgery with topographic anatomy and a course in stomatology of the medical faculty named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture
125368, Moscow, Freedom Street, bld. 34, str. 1;
432071, Ulyanovsk Region, Ulyanovsk, Leo Tolstoy Street, bld. 42
A. V. Smolkina
Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University
Russian Federation
Russian Federation
Smolkinа Antonina Vasilyevna – Doctor of Medical Sciences, Professor, Head of the Department of General and Operative Surgery with Topographic Anatomy and a Course in Stomatology of the Medical Faculty named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture
432071, Ulyanovsk Region, Ulyanovsk, Leo Tolstoy Street, bld. 42
E. A. Toneev
Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University;
State Healthcare Institution Regional Oncological Dispensary
Russian Federation
Russian Federation
Toneev Evgeny Alexandrovich – Candidate of Medical Sciences, thoracic surgeon of the surgical department of thoracic oncology; Associate Professor of the Department of Hospital Surgery, Anesthesiology, Reanimation, Urology, Traumatology and Orthopedics of the Medical Faculty named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture
SCOPUS ID: 1043371
432078, Ulyanovsk Region, Ulyanovsk, September 12th Street, bld. 90;
432071, Ulyanovsk Region, Ulyanovsk, Leo Tolstoy Street, bld. 42
R. F. Shagdaleev
Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University
Russian Federation
Russian Federation
Shagdaleev Roman Fatykhovich – Assistant, intern of the Department of Hospital Surgery, Anesthesiology, Reanimation, Urology, Traumatology and Orthopedics of the Faculty of Dentistry, Pharmacy and Postgraduate Medical Education, Institute of Medicine, Ecology and Physical Culture
SCOPUS ID: 1245970
432071, Ulyanovsk Region, Ulyanovsk, Leo Tolstoy Street, bld. 42
E. A. Keshyan
State Budgetary Healthcare Institution “City Clinical Hospital 15 named after O.M. Filatov Department of Health of Moscow"
Russian Federation
Russian Federation
Keshyan Erik Ashatovich – Candidate of Medical Sciences, surgeon of the surgical department; Assistant of the Department of Hospital Surgery 1
111539, Moscow, Veshnyakovskaya Street, bld. 23;
117997, Moscow, Ostrovityanova Street, bld. 1,
N. I. Belonogov
Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University
Russian Federation
Russian Federation
Belonogov Nikolay Ivanovich – Doctor of Medical Sciences, Professor of the Department of Hospital Surgery
432071, Ulyanovsk Region, Ulyanovsk, Leo Tolstoy Street, bld. 42
A. B. Guseynov
State Budgetary Healthcare Institution “City Clinical Hospital 15 named after O.M. Filatov Department of Health of Moscow"
Russian Federation
Russian Federation
Huseynov Alim Bandar ogly – surgeon of the 1st surgical department
111539, Moscow, Veshnyakovskaya Street, bld. 23
References
1. Osińska M., Rysiak E., Zaręba R., Worona P., Kazberuk A., Prokop I., Celińska-Janowicz K., Zaręba I. Zakażenia szpitalne w aspekcie prawnym. Anestezjologia i Ratownictwo, 2018, № 12, рр. 353–356.
2. Horan T.C., Gaynes R.P., Martone W.J., Jarvis W.R., Emori T.G. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infection Control and Hospital Epidemiology, 1992, № 13(10), рр. 606–608.
3. Perioperative antibiotic prophylaxis in abdominal surgery. Handbook for physicians / Edited by V.D. Fedorov, V.G. Pleshkov, L.S. Strachunsky. – Smolensk, 2004. 18 p. (In Russ.)
4. Aslanov B.I., Zueva L.P., Kolosovskaya E.N., Lyubimova A.V., Horoshilov V.Yu., Dolgiy A.A., et al. Principles of organizing perioperative antibiotic prophylaxis in healthcare facilities. Federal Clinical Guidelines. Moscow: 2007, 42 p. (In Russ.)
5. Certificate of State Registration of the Database № 2024622259, Russian Federation. Infections at the Site of Surgical Intervention After Planned Thoracotomies: № 2024621965, appl. 13.05.2024, publ. 24.05.2024 / Kulikov V.D., Danilova L.A., Vdovin A.M., Midlenko O.V., Martynov A.A., Toneev E.A., Shagdaleev R.F., Prokhorov D.D., Pavlov M.O., Murtazin A.R., Martynova E.V., Mukhutdinova A.N., Nuretdinov D.I. – EDN KKVHFX. (In Russ.)
6. Bailey I.S., Karran S.E., Toyn K. Community surveillance of complications after hernia surgery. BMJ, 1992, № 304(6825), рр. 469–471.
7. Podzolkova L.N. The importance of “clean” rooms in the fight against surgical infections. Khirurg, 2019, № 8, рр. 57–66. (In Russ.)
8. Serpa Neto A., Hemmes S.N., Barbas C.S., Beiderlinden M., Fernandez-Bustamante A., Futier E., Hollmann M.W., Jaber S., Kozian A., Licker M., Lin W.Q., Moine P., Scavonetto F., Schilling T., Selmo G., Severgnini P., Sprung J., Treschan T., Unzueta C., Weingarten T.N., PROVE Network investigators. Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and meta-analysis. The Lancet Respiratory Medicine, 2014, № 2(12), рр. 1007–1015. https://doi.org/10.1016/S2213-2600(14)70228-0
9. Bernard A., Pillet M., Goudet P., Viard H. Antibiotic prophylaxis in pulmonary surgery. A prospective randomized double-blind trial of flash cefuroxime versus forty-eight-hour cefuroxime. The Journal of Thoracic and Cardiovascular Surgery, 1994, № 107(3), рр. 896–900.
10. Imperatori A., Nardecchia E., Dominioni L., Sambucci D., Spampatti S., Feliciotti G., Rotolo N. Surgical site infections after lung resection: a prospective study of risk factors in 1,091 consecutive patients. Journal of Thoracic Disease, 2017, № 9(9), рр. 3222–3231. https://doi.org/10.21037/jtd.2017.08.122
11. Cheuk N., Worth L.J., Tatoulis J., Skillington P., Kyi M., Fourlanos S. The relationship between diabetes and surgical site infection following coronary artery bypass graft surgery in current-era models of care. The Journal of Hospital Infection, 2021, № 116, рр. 47–52. https://doi.org/10.1016/j.jhin.2021.07.009
12. Licker M., Spiliopoulos A., Frey J.G., Robert J., Höhn L., de Perrot M., Tschopp J.M. Risk factors for early mortality and major complications following pneumonectomy for non-small cell carcinoma of the lung. Chest, 2002, № 121(6), рр. 1890–1897. https://doi.org/10.1378/chest.121.6.1890
13. Rueth N.M., Parsons H.M., Habermann E.B., Groth S.S., Virnig B.A., Tuttle T.M., Andrade R.S., Maddaus M.A., D’Cunha J. Surgical treatment of lung cancer: predicting postoperative morbidity in the elderly population. The Journal of Thoracic and Cardiovascular Surgery, 2012, № 143(6), рр. 1314–1323. https://doi.org/10.1016/j.jtcvs.2011.09.072
14. Cheng H., Chen B.P., Soleas I.M., Ferko N.C., Cameron C.G., Hinoul P. Prolonged Operative Duration Increases Risk of Surgical Site Infections: A Systematic Review. Surgical Infections (Larchmt), 2017, № 18(6), рр. 722–735. https://doi.org/10.1089/sur.2017.089
Review
For citations:
Vdovin A.M., Smolkina A.V., Toneev E.A., Shagdaleev R.F., Keshyan E.A., Belonogov N.I., Guseynov A.B. Surgical site infections after lung resection. Moscow Surgical Journal. 2025;(2):88-96. (In Russ.) https://doi.org/10.17238/2072-3180-2025-2-88-96
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