Study of the peculiarities of lymphotropic therapy in the background of the experimentally developed model of ulcerant colitis
https://doi.org/10.17238/2072-3180-2023-1-73-81
Abstract
Introduction. Purpose of work: to study the features of lymphotropic therapy against the background of an experimentally created model of ulcerative colitis to improve the result of surgical treatment of this pathology using endomesentericlymphotropic therapy in the postoperative period in the complex treatment.
Material and methods. The analysis of the results of 4 series of experimental experiments performed on 24 outbred dogs was carried out. The aim of the experiment was to model ulcerative colitis, and before and against the background of the created model to study the role of the regional lymphatic system of the abdominal organs in its treatment using lymphotropic therapy. Literature data on the creation of a model of ulcerative colitis in the experiment were studied in detail.The most optimal and acceptable was the chemically induced model of ulcerative colitis, which was caused by rectal administration of acetic acid.
Results. The results obtained with the created model of ulcerative colitis in experimental animals show a sharp slowdown in the rate of lymphatic drainage in the intestinal mesentery by two or more times compared to normal. After lymphostimulation against the background of the created model of ulcerative colitis, lymphatic drainage in the intestinal mesentery improves, while eliminating lymphostasis in the "lymphatic collector", which develops during the inflammatory process.Against the background of lymphostimulation, lymphotropically used drugs contribute to the prevention of possibly developing undesirable complications in the postoperative period. The conducted experiments convincingly prove the positive aspects of the use of lymphotropic therapy in the postoperative period.
About the Authors
Yu. S. Egamov
Andijan State Medical Institute
Uzbekistan
Uzbekistan
Egamov Yuldashali Sulaymanovich – Doctor of Medical Sciences, Professor
Atabekov street 1, Andijan city, 170127
A. E. Ruziev
Bukhara StateMedical Institute
Uzbekistan
Uzbekistan
Ruziev Akhtam Ergashovich – Doctor of Philosophy in Medicine (PhD), Associate Professor
A. Navai str., 1, Bukhara, 200100
Kh. B. Durdiyv
Andijan State Medical Institute
Uzbekistan
Uzbekistan
Durdiyv Khamdam Bazarbaevich – doctoral student of the Department of General Surgery
Atabekov street 1, Andijan city, 170127
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Review
For citations:
Egamov Yu.S., Ruziev A.E., Durdiyv Kh.B. Study of the peculiarities of lymphotropic therapy in the background of the experimentally developed model of ulcerant colitis. Moscow Surgical Journal. 2023;(1):73-81. (In Russ.) https://doi.org/10.17238/2072-3180-2023-1-73-81
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