Analysis of the effectiveness of complex rehabilitation of patients with melanoma of the skin after combined treatment: the results of the study
https://doi.org/10.17238/2072-3180-2023-1-57-63
Abstract
Introduction. Despite the wide range of complications associated with the use of antitumor therapy, patients often do not receive preventive treatment necessary to correct the consequences for the body.
The purpose of the study. Analysis of the effectiveness of complex rehabilitation programs in patients with skin melanoma after combined treatment.
Materials and methods. The study included 90 patients with metastatic melanoma of the skinwith a history of surgical treatment for the underlying disease; who received immunotherapy with nivolumab or pembrolizumab during the study period. The main group (n=48) included patients who underwent a comprehensive rehabilitation program. Patients who did not complete the rehabilitation program formed a control group (n=42). The effectiveness of immunotherapy was evaluated in accordance with the iRECIST 1.1 criteria.
Results. Stabilization was registered in 17 (35,4%) patients of the main group and in 16 (38,1%) patients of the control group; the incidence of disease progression in both groups was comparable: 9 (18,8%) cases in the main group and 10 (23,8%) cases in the control group.
Conclusion. The use of complex rehabilitation programs in the treatment of patients with melanoma demonstrates its clinical effectiveness, however, there are a number of important issues that require further resolution.
About the Authors
A. S. Mochalova
Clinical Hospital №1 Joint Stock Company"Group of companies “Medsi”
Russian Federation
Russian Federation
Mochalova Anastasia Sergeevna – Candidate of Medical Sciences, Head of the Department of Antitumor Drug Therapy
143442, Build. 1A, possession 2, vil. Otradnoe, Moscow region, Krasnogorsk
I. V. Semenyakin
Clinical Hospital №1 Joint Stock Company"Group of companies “Medsi”
Russian Federation
Russian Federation
Semenyakin Igor Vladimirovich – Doctor of Medical Sciences, Professor
143442, Build. 1A, possession 2, vil. Otradnoe, Moscow region, Krasnogorsk
M. O. Senchilov
Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Senchilov Mikhail Olegovich – Student
119991, Build. 2, 8 Trubetskaya St., Moscow
V. S. Fomin
Veresaev City Clinical Hospital
Russian Federation
Russian Federation
Fomin Vladimir Sergeevich – Candidate of Medical Sciences, Associate Professor
127644, st. Lobnenskaya, 10, Moscow
References
1. Rehabilitation 2030 Initiative. World Health Organization, 2022. Available at: https://www.who.int/initiatives/rehabilitation-2030. (Accessed 13.01.2023)
2. On approval of the list of initiatives of socio-economic development of the Russian Federation until 2030. Order of the Government of the Russian Federation of 06.10.2021 N 2816-r (ed. dated 14.03.2022) http://www.pravo.gov.ru (Accessed 13.01.2023). (In Russian).
3. Sleight A., Gerber L.H., Marshall T.F., Livinski A., Alfano C.M., Harrington S., et al. Systematic Review of Functional Outcomes in Cancer Rehabilitation. Arch Phys Med Rehabil., 2022, № 103, pp. 1807–1826. https://doi.org/10.1016/j.apmr.2022.01.142
4. Dhanyamraju P.K., Patel T.N. Melanoma therapeutics: a literature review. J Biomed Res, 2022, № 36, pp. 77–97. https://doi.org/10.7555/JBR.36.20210163
5. Curti B.D., Faries M.B. Recent Advances in the Treatment of Melanoma. N Engl J Med., 2021, № 384, pp. 2229–2240. https://doi.org/10.1056/NEJMra2034861
6. Bucio D., Bertram J. The Effect of Cancer Rehabilitation on Functional Outcomes in a Patient with Stage IV Melanoma with Subsequent Brain Metastases: A Case Report. Rehabil Oncol, 2022, № 40, pp. 27. https://doi.org/10.1097/01.REO.0000000000000295
7. Muscaritoli M., Arends J., Bachmann P., Baracos V., Barthelemy N., Bertz H., et al. ESPEN practical guideline: Clinical Nutrition in cancer. Clin Nutr, 2021, №40, pp. 2898–2913. https://doi.org/10.1016/j.clnu.2021.02.005
8. Schmitz K.H., Courneya K.S., Matthews C., Demark-Wahnefried W., Galvão D.A., Pinto B.M., et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc., 2010, № 42, pp. 1409–1426. https://doi.org/10.1249/MSS.0b013e3181e0c112
9. Donnelly D., Bajaj S., Yu J., Hsu M., Balar A., Pavlick A., et al. The complex relationship between body mass index and response to immune checkpoint inhibition in metastatic melanoma patients. J Immunother Cancer, 2019, № 7, pp. 222. https://doi.org/10.1186/s40425-019-0699-5
10. Johannet P., Sawyers A., Qian Y., Kozloff S., Gulati N., Donnelly D., et al. Baseline prognostic nutritional index and changes in pretreatment body mass index associate with immunotherapy response in patients with advanced cancer. J Immunother Cancer, 2020, № 8. https://doi.org/10.1136/jitc-2020-001674
Review
For citations:
Mochalova A.S., Semenyakin I.V., Senchilov M.O., Fomin V.S. Analysis of the effectiveness of complex rehabilitation of patients with melanoma of the skin after combined treatment: the results of the study. Moscow Surgical Journal. 2023;(1):57-63. (In Russ.) https://doi.org/10.17238/2072-3180-2023-1-57-63
Views:
284
Email this article 