Perspectives of endoscopic treatment for patients with heterotopic gastric mucosa in the cervical esophagus (literature review)
https://doi.org/10.17238/2072-3180-2022-4-114-123
Abstract
In recent years, there has been growing interest in heterotopiс gastric mucosa (HGM) in the cervical esophagus. The management of patients with symptoms of laryngo-pharyngeal reflux (LPR) is unresolved issue. Methods of treatment are debatable, there are no clear strategies for HGM. Most authors report about low efficiency of conservative therapy. Radical surgical methods are historical in nature. Endoscopic methods of treatment deserve the greatest attention. The most invasive endoscopic approaches of treatment such as mucosal resection and submucosal dissection are used for neoplastic transformations of HGM in cervical esophagus. Argon plasma coagulation (APC) and radiofrequency ablation (RFA) provides good results aimed at eradicating of HGM in the esophagus and clinical symptoms. Pay attention to localization of heterotopia and potential risk of esophageal stricture formation, preference should be given to the safest technique RFA. The variety of minimally invasive technologies of treatment of symptomatic patients with HGM in the esophagus requires further research to develop standardized approach of therapy.
About the Authors
A. O. Khikhlova
Department of Hospital Surgery of South-Ural State Medical University; GBUZ Chelyabinsk Regional Clinical Hospital
Russian Federation
Russian Federation
Khikhlova Alina Olegovna – Postgraduate student at the Department of Hospital Surgery; Endoscopist of Endoscopy Department
70, bld. 5, Vorovskogo St., Chelyabinsk, 454141
E. R. Olevskaya
Department of Hospital Surgery of South-Ural State Medical University; GBUZ Chelyabinsk Regional Clinical Hospital
Russian Federation
Russian Federation
Olevskaya Elena Rafailovna – Doctor of Medical Sciences; Endoscopy Department Head
70, bld. 5, Vorovskogo St., Chelyabinsk, 454141
A. I. Dolgushina
South-Ural State Medical University
Russian Federation
Russian Federation
Dolgushina Anastasia Ilinichna – Doctor of Medical Sciences,
Hospital Therapy Department Head
70, bld. 8, Vorovskogo St., Chelyabinsk, 454141
References
1. López-Colombo A., Jiménez-Toxqui M., Gogeascoechea-Guillén P.D., Meléndez-Mena D., Morales-Hernández E.R., Montiel-Jarquín Á.J., Amaro-Balderasa E. Prevalence of esophageal inlet patch and clinical characteristics of the patients. Rev Gastroenterol Mex., 2019, № 84(4), pp. 442–448. https://doi.org/10.1016/j.rgmx.2018.07.003
2. Blanco C., Teusabá E., Russi K. A Case Report of Circumferential Presentation with Stricture of Heterotopic Gastric Mucosa in the Cervical Esophagus. Revista Colombiana De Gastroenterología, 2015, № 30(2), pp. 225–231. https://doi.org/10.22516/25007440.45
3. Al-Mammari S., Selvarajah U., East J.E., Bailey A.A., Braden B. Narrow band imaging facilitates detection of inlet patches in the cervical oesophagus. Dig Liver Dis., 2014, № 46(8), pp. A237. https://doi.org/10.1016/j.dld.2014.05.001
4. Ciocalteu A., Popa P., Ionescu M., Gheonea D.I. Issues and controversies in esophageal inlet patch. World J Gastroenterol., 2019, № 25(30), pp. 4061–4073. https://doi.org/10.3748/wjg.v25.i30.4061
5. Chong V.H. Clinical significance of heterotopic gastric mucosal patch of the proximal esophagus. World J Gastroenterol., 2013, №19(3), pp. 331–338. https://doi.org/10.3748/wjg.v19.i3.331
6. Peitz U., Vieth M., Evert M., Arand J., Roessner A., Malfertheiner P. The prevalence of gastric heterotopia of the proximal esophagus is underestimated, but preneoplasia is rare – correlation with Barrett’s esophagus. BMC Gastroenterol., 2017, № 17(1). https://doi.org/10.1186/s12876-017-0644-3
7. Korkut E., Bektaş M., Alkan M., Ustün Y., Meco C., Ozden A., Soykan I. Esophageal motility and 24-h pH profiles of patients with heterotopic gastric mucosa in the cervical esophagus. Eur J Intern Med., 2010, № 21(1), pp. 21–24. https://doi.org/10.1016/j.ejim.2009.10.009
8. Chong V.H., Jalihal A. Heterotopic gastric mucosal patch of the esophagus is associated with higher prevalence of laryngopharyngeal reflux symptoms. Eur Arch Otorhinolaryngol., 2010, № 267(11), pp.1793–1799. https://doi.org/10.1007/s00405-010-1259-2
9. Gutierrez O., Akamatsu T., Cardona H., Graham D.Y., El-Zimaity H.M. Helicobacter pylori and hetertopic gastric mucosa in the upper esophagus (the inlet patch). Am J Gastroenterol., 2003, № 98(6), pp. 1266–1270. https://doi.org/10.1111/j.1572-0241.2003.07488.x
10. Kristo I., Rieder E., Paireder M., Schwameis K., Jomrich G., Dolak W., Parzefall T., Riegler M., Asari R., Schoppmann S.F. Radiofrequency ablation in patients with large cervical heterotopic gastric mucosa and globus sensation: Closing the treatment gap. Dig Endosc., 2018, № 30(2), pp. 212–218. https://doi.org/10.1111/den.12959
11. Leclercq P., Jadot V., Bours V., Kohnen L., Honoré P., Martin M., De Flines J., Mutijima E., Leclercq P. Inherited CDH1 pathogenic variant: is there a place for surveillance of esophageal gastric inlet patch? Therap Adv Gastroenterol., 2020, № 13, pp. 1–2. https://doi.org/10.1177/1756284820916399
12. Sahin G., Adas G., Koc B. et al. Is cervical inlet patch important clinical problem? Int J Biomed Sci., 2014, № 10(2), pp. 129–135.
13. Jadot V., Segers K., Bours V., Kohnen L., Honoré P., Martin M., De Flines J., Mutijima E., Leclercq P. Cancer gastrique diffus héréditaire. Série de 8 patients appartenant à une même famille et revue de la littérature [Hereditary diffuse gastric cancer: case serie of 8 patients from a single family and literature review]. Rev Med Liege., 2019, № 74(3), pp. 134–138.
14. Rusu R., Ishaq S., Wong T., Dunn J.M. Cervical inlet patch: new insights into diagnosis and endoscopic therapy. Frontline Gastroenterol., 2018, № 9(3), pp. 214–220. https://doi.org/10.1136/flgastro-2017-100855
15. Akanuma N., Hoshino I., Akutsu Y., Shuto K., Shiratori T., Kono T., Uesato M., Sato A., Isozaki Y., Maruyama T., Takeshita N., Matsubara H. Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case. Surg Today., 2013, № 43(4), pp. 446–451. https://doi.org/10.1007/s00595-012-0206-9
16. Domm A.B., Sarskan S., Cheng D., Conklin J.L., Lo S.K. Esophageal Inlet Patch Removal Using Endoscopic Mucosal Resection. Gastrointestinal Endoscopy, 2007, № 65(5), pp. AB148. https://doi.org/10.1016/j.gie.2007.03.20210.1016/j.gie.2007.03.202
17. Basseri B., Conklin J.L., Mertens R.B., Lo S.K., Bellack G.S., Shaye O.A. Heterotopic gastric mucosa (inlet patch) in a patient with laryngopharyngeal reflux (LPR) and laryngeal carcinoma: a case report and review of literature. Dis Esophagus., 2009, № 22(4), pp. E1–E5. https://doi.org/10.1111/j.1442-2050.2008.00915.x
18. Cock C., Hamarneh Z. Gastric inlet patches: symptomatic or silent? Curr Opin Otolaryngol Head Neck Surg., 2019, № 27(6), pp. 453–462. https://doi.org/10.1097/MOO.0000000000000581
19. Cartabuke R.H., Thota P.N. High-grade dysplasia in thoracic inlet patch treated by focal endoscopic mucosal resection and radiofrequency ablation. Gastrointest Endosc., 2015, № 81(5), pp. 1297–1298. https://doi.org/10.1016/j.gie.2014.12.004
20. Kadota T., Fujii S., Oono Y., Imajoh M., Yano T., Kaneko K. Adenocarcinoma arising from heterotopic gastric mucosa in the cervical esophagus and upper thoracic esophagus: two case reports and literature review. Expert Rev Gastroenterol Hepatol., 2016, № 10(3), pp. 405–414. https://doi.org/10.1586/17474124.2016.1125780
21. Probst A., Schaller T., Messmann H. Adenocarcinoma arising from ectopic gastric mucosa in an esophageal inlet patch: treatment by endoscopic submucosal dissection. Endoscopy, 2015, № 47, pp. E337–E338. https://doi.org/10.1055/s-0034-1392423
22. Oono Y., Kensuke S., Yoda Y., Hori K., Ikematsu H., Yano T. Cervical esophageal adenocarcinoma arising from heterotopic gastric mucosa, treated with endoscopic submucosal dissection. Endoscopy, 2019, № 51(2), pp. E28–E29. https://doi.org/10.1055/a-0767-6253
23. Kitasaki N., Hamai Y., Yoshikawa T., Emi M., Kurokawa T., Hirohata R., Ohsawa M., Okada M. Recurrent esophageal adenocarcinoma derived from ectopic gastric mucosa: A case report. Thorac Cancer., 2022, № 13(6), pp. 876–879. https://doi.org/10.1111/1759-7714.14339
24. Shimamura Y., Winer S., Marcon N. A Giant Circumferential Inlet Patch With Acid Secretion Causing Stricture. Clin Gastroenterol Hepatol., 2017, № 15(4), pp. A22–A23. https://doi.org/10.1016/j.cgh.2016.10.004
25. Godzhello E. A., Bulganina N. A., Khrustaleva M. V. Heterotopia of gastric mucosa and long segmental Barrett’ oesophagus complicated by cicatricial stricture of the upper third of the oesophagus. Experimental and Clinical Gastroenterology, 2021, № 189(5), pp. 92–96. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-189-5-92-96
26. Sauvé G., Croué A., Denez B., Boyer J. High-grade dysplasia in heterotopic gastric mucosa in the upper esophagus after radiotherapy: successful eradication 2 years after endoscopic treatment by argon plasma coagulation. Endoscopy, 2001, № 33(8), pp. 732. https://doi.org/10.1055/s-2001-16221
27. Meining A., Bajbouj M., Preeg M., Reichenberger J., Kassem A.M., Huber W., Brockmeyer S.J., Hannig C., Höfler H., Prinz C., Schmid R.M. Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial. Endoscopy, 2006, № 38(6), pp. 566–570. https://doi.org/10.1055/s-2006-925362
28. Meining A., Bajbouj M. Gastric inlet patches in the cervical esophagus: what they are, what they cause, and how they can be treated. Gastrointest Endosc., 2016, № 84(6), pp. 1027–1029. https://doi.org/10.1016/j.gie.2016.08.012
29. Bajbouj M., Becker V., Eckel F., Miehlke S., Pech O., Prinz C., Schmid R.M., Meining A. Argon plasma coagulation of cervical heterotopic gastric mucosa as an alternative treatment for globus sensations. Gastroenterology, 2009, № 137(2), pp. 440–444. https://doi.org/10.1053/j.gastro.2009.04.053
30. Klare P., Meining A., von Delius S. Wolf P., Konukiewitz B., Schmid R.M., Bajbouj M. Argon plasma coagulation of gastric inlet patches for the treatment of globus sensation: it is an effective therapy in the long term. Digestion, 2013, № 88(3), pp. 165–171. https://doi.org/10.1159/000355274
31. Di Nardo G., Cremon C., Bertelli L., Oliva S., De Giorgio R., Pagano N. Esophageal Inlet Patch: An Under-Recognized Cause of Symptoms in Children. J Pediatr., 2016, pp. 99–104. https://doi.org/10.1016/j.jpeds.2016.05.059
32. ASGE Technology Committee, Navaneethan U., Thosani N., Goodman A., Manfredi M., Pannala R., Parsi M.A., Smith Z.L., SullivanS.A., Banerjee S., Maple J.T. Radiofrequency ablation devices. VideoGIE, 2017, № 2(10), pp. 252–259. https://doi.org/10.1016/j.vgie.2017.06.002
33. Dunn J.M., Sui G., Anggiansah A., Wong T. Radiofrequency ablation of symptomatic cervical inlet patch using a through-the-scope device: a pilot study. Gastrointest Endosc., 2016, № 84(6), pp. 1022–1026. https://doi.org/10.1016/j.gie.2016.06.037
Review
For citations:
Khikhlova A.O., Olevskaya E.R., Dolgushina A.I. Perspectives of endoscopic treatment for patients with heterotopic gastric mucosa in the cervical esophagus (literature review). Moscow Surgical Journal. 2022;(4):114-123. (In Russ.) https://doi.org/10.17238/2072-3180-2022-4-114-123
Views:
1906
Email this article 