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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mossj</journal-id><journal-title-group><journal-title xml:lang="ru">Московский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Moscow Surgical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-3180</issn><publisher><publisher-name>ООО «ПРОФИЛЬ – 2С»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/2072-3180-2024-4-253-262</article-id><article-id custom-type="elpub" pub-id-type="custom">mossj-872</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛИТЕРАТУРНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERARY REVIEWS</subject></subj-group></article-categories><title-group><article-title>Значение маркеров системного воспаления в согласительных рекомендациях по лечению хирургических заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>The significance of markers of systemic inflammation in conciliatory recommendations for the treatment of surgical diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8977-6179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карсанов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karsanov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карсанов Алан Мухарбекович – к.м.н., доцент кафедры хирургических болезней № 3,</p><p>362003, Республика Северная Осетия-Алания, Владикавказ, ул. Пушкинская, д. 40</p></bio><bio xml:lang="en"><p>Karsanov Alan Mukharbekovich – Candidate of Medical Sciences, Associate Professor of the Department of Surgery № 3,</p><p>362025, st. Pushkinskaya, 40, Vladikavkaz, North Ossetia-Alania state</p></bio><email xlink:type="simple">karsan@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5773-6196</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лагкуев</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Lagkuev</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лагкуев Магомет Джабраилович – заместитель главного врача,</p><p>362003, Республика Северная Осетия-Алания, Владикавказ, ул. Барбашова, 39</p></bio><bio xml:lang="en"><p>Lagkuev Magomet Dzhabrailovich – Deputy chief physician,</p><p>362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania</p></bio><email xlink:type="simple">rkb@minzdrav.alania.gov.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5722-4869</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асатрян</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Asatryan</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Асатрян Аршавир Самвелович – заведующий отделением колопроктологии,</p><p>362003, Республика Северная Осетия-Алания, Владикавказ, ул. Барбашова, 39</p></bio><bio xml:lang="en"><p>Asatryan Arshavir Samvelovich – Head of the Department of Coloproctology,</p><p>362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania</p></bio><email xlink:type="simple">karsan@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-8317-5835</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубулова</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khubulova</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хубулова Дина Аршаковна – к.м.н., доцент кафедры хирургических болезней №3,</p><p>362003, Республика Северная Осетия-Алания, Владикавказ, ул. Пушкинская, д. 40</p></bio><bio xml:lang="en"><p>Khubulova Dina Arshakovna – Candidate of Medical Sciences, Associate Professor of the Department of Surgery № 3,</p><p>362025, st. Pushkinskaya, 40, Vladikavkaz, North Ossetia-Alania state</p></bio><email xlink:type="simple">dina.khubulova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-7436-2875</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плиев</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pliev</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плиев Марат Валерьевич – заведующий отделением сочетанной травмы,</p><p>362003, Республика Северная ОсетияАлания, Владикавказ, ул. Барбашова, 39</p></bio><bio xml:lang="en"><p>Pliev Marat Valerievich – Head of the Combined Trauma Department,</p><p>362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania</p></bio><email xlink:type="simple">rkb@minzdrav.alania.gov.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-7015-6185</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ляднов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyadnov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ляднов Артур Маратович – врач-хирург,</p><p>362003, Республика Северная Осетия-Алания, Владикавказ, ул. Барбашова, 39</p></bio><bio xml:lang="en"><p>Lyadnov Artur Maranjvich – Surgeon, </p><p>362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania</p></bio><email xlink:type="simple">karsan@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-8844-9278</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзуцев</surname><given-names>В. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzutsev</surname><given-names>V. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дзуцев Виталий Русланович – заведующий отделением сосудистой хирургии</p><p>362003, Республика Северная Осетия-Алания, Владикавказ, ул. Барбашова, 39</p></bio><bio xml:lang="en"><p>Dzutsev Vitaliy Ruslanovich – Head of the Department of vascular surgery,</p><p>362003, st. Barbashova, 39, Vladikavkaz, North Ossetia-Alania</p></bio><email xlink:type="simple">rkb@minzdrav.alania.gov.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5275-4213</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маскин</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Maskin</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маскин Сергей Сергеевич – д.м.н., профессор, заведующий кафедрой госпитальной хирургии,</p><p>400131, Волгоград, площадь Павших Борцов, д. 1</p></bio><bio xml:lang="en"><p>Maskin Sergey Sergeevich – Doctor of Medical Sciences, Professor, head of the Department of hospital surgery,</p><p>400131, Pavshikh Bortsov Sq., Volgograd</p></bio><email xlink:type="simple">maskins@bk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Осетинская государственная медицинская академия» Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North Ossetian State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ Республиканская клиническая больница Минздрава РСО-Алания</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Волгоградский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2024</year></pub-date><volume>0</volume><issue>4</issue><fpage>253</fpage><lpage>262</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карсанов А.М., Лагкуев М.Д., Асатрян А.С., Хубулова Д.А., Плиев М.В., Ляднов А.М., Дзуцев В.Р., Маскин С.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Карсанов А.М., Лагкуев М.Д., Асатрян А.С., Хубулова Д.А., Плиев М.В., Ляднов А.М., Дзуцев В.Р., Маскин С.С.</copyright-holder><copyright-holder xml:lang="en">Karsanov A.M., Lagkuev M.D., Asatryan A.S., Khubulova D.A., Pliev M.V., Lyadnov A.M., Dzutsev V.R., Maskin S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mossj.ru/jour/article/view/872">https://www.mossj.ru/jour/article/view/872</self-uri><abstract><sec><title>Введение</title><p>Введение. Потребность в высокочувствительных и высокоспецифичных маркерах системного воспаления (МВ) при большинстве экстренных хирургических заболеваний остается актуальной научно-клинической задачей.</p></sec><sec><title>Результаты</title><p>Результаты. Статья посвящена описанию основных характеристик наиболее доступных МВ, используемых при абдоминальных заболеваниях. Так при остром аппендиците рекомендована оценка уровня С-реактивного белка и прокальцитонина не только для первичной диагностики, но и в качестве дифференциального критерия между неосложненной и осложненной формой заболевания. Использование МВ у пациентов с подозрением на острый холецистит имеет даже большее значение, чем при иных острых абдоминальных заболеваниях, поскольку ранняя стратификация когорт по тяжести заболевания имеет в данной популяции пациентов решающее значение для сроков и объема хирургического лечения. Присутствие и различная тяжесть фазы асептического воспаления, а тем более развитие инфицированного острого панкреатита, не оставляют никаких иных вариантов, как осуществлять у пациентов мониторинг не только витальных функций, но и динамику концентрации МВ. Неспецифичность симптоматики, широкая вариабельность клинико-морфологических проявлений внутрибрюшного воспаления легли в основу рекомендаций по обязательному определению уровня C-реактивного белка в сыворотке крови у пациентов с острыми дивертикулитами.</p></sec><sec><title>Выводы</title><p>Выводы. Эффективные МВ должны использоваться в неотложной абдоминальной хирургии не только для ранней верификации воспалительного генеза болезненного состояния пациента, выбора оптимального лечебного компонента, но и для прогноза, а особенно – мониторинга за течением заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The need for highly sensitive and highly specific markers of systemic inflammation (MI) in most emergency surgical diseases remains an urgent scientific and clinical task.</p></sec><sec><title>Results</title><p>Results. The article is devoted to the description of the main characteristics of the most accessible MI used in abdominal diseases. Thus, in acute appendicitis, it is recommended to assess the level of C-reactive protein and procalcitonin not only for primary diagnostics, but also as a differential criterion between uncomplicated and complicated forms of the disease. The use of MI in patients with suspected acute cholecystitis is even more important than in other acute abdominal diseases, since early stratification of cohorts by disease severity is crucial for the timing and extent of surgical treatment in this patient population. The presence and varying severity of the aseptic inflammation phase, and especially the development of infected acute pancreatitis, leave no other options than to monitor not only vital functions in patients, but also the dynamics of MI concentration. Non-specificity of symptoms, wide variability of clinical and morphological manifestations of intra-abdominal inflammation formed the basis for recommendations on mandatory determination of the level of C-reactive protein in the blood serum of patients with acute diverticulitis.</p></sec><sec><title>Conclusions</title><p>Conclusions. Effective MI should be used in emergency abdominal surgery not only for early verification of the inflammatory genesis of the patient's painful condition, selection of the optimal therapeutic component, but also for prognosis, and especially for monitoring the course of the disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хирургия</kwd><kwd>биологические маркеры</kwd><kwd>системное воспаление</kwd><kwd>С-реактивный белок</kwd><kwd>прокальцитонин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>surgery</kwd><kwd>biological markers</kwd><kwd>systemic inflammation</kwd><kwd>C-reactive protein</kwd><kwd>procalcitonin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хирургическая помощь в Российской Федерации. 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