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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mossj</journal-id><journal-title-group><journal-title xml:lang="ru">Московский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Moscow Surgical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-3180</issn><publisher><publisher-name>ООО «ПРОФИЛЬ – 2С»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/2072-3180-2024-3-196-203</article-id><article-id custom-type="elpub" pub-id-type="custom">mossj-832</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Острый аппендицит у пожилых пациентов как нетривиальная клиническая задача</article-title><trans-title-group xml:lang="en"><trans-title>Acute appendicitis in elderly patients as a non-trivial clinical problem</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8977-6179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карсанов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karsanov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карсанов Алан Мухарбекович – к.м.н., доцент кафедры хирургических болезней №3,</p><p>362003, г. Владикавказ, ул. Пушкинская, д. 40.</p></bio><bio xml:lang="en"><p>Karsanov Alan Mukharbekovich – Candidate of Medical Sciences, Associate Professor of the Department of Surgery No. 3,</p><p>40, Pushkinskaya st., Vladikavkaz, 362025.</p></bio><email xlink:type="simple">karsan@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-7353-4484</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поплавский</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Poplavskiy</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Поплавский Олег Владимирович – врач-хирург,</p><p>362003, г. Владикавказ, ул. Барбашова, 39.</p></bio><bio xml:lang="en"><p>Poplavskiy Oleg Vladimirovich – Surgeon,</p><p>39, Barbashova st., Vladikavkaz, 362003.</p></bio><email xlink:type="simple">rkb@minzdrav.alania.gov.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-2841-9421</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валиев</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Valiev</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валиев Руслан Валентинович – заведующий хирургическим отделением,</p><p>362003, г. Владикавказ, ул. Барбашова, 39.</p></bio><bio xml:lang="en"><p>Valiev Ruslan V. – Head of the Department of Surgery, </p><p>39, Barbashova st., Vladikavkaz, 362003.</p></bio><email xlink:type="simple">rkb@minzdrav.alania.gov.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5722-4869</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асатрян</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Asatryan</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Асатрян Аршавир Самвелович – заведующий отделением колопроктологии,</p><p>362003, г. Владикавказ, ул. Барбашова, 39.</p></bio><bio xml:lang="en"><p>Asatryan Arshavir Samvelovich – Head of the Department of Coloproctology,</p><p>39, Barbashova st., Vladikavkaz, 362003.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-3378-5735</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гамаонов</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gamaonov</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гамаонов Роберт Семенович – врач-хирург,</p><p>362003, г. Владикавказ, ул. Барбашова, 39.</p></bio><bio xml:lang="en"><p>Gamaonov Robert Semenovich – Surgeon,</p><p>39, Barbashova st., Vladikavkaz, 362003.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-8317-5835</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубулова</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khubulova</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хубулова Дина Аршаковна – к.м.н., доцент кафедры хирургических болезней №3,</p><p>362003, г. Владикавказ, ул. Пушкинская, д. 40.</p></bio><bio xml:lang="en"><p>Khubulova Dina Arshakovna – Candidate of Medical Sciences, Associate Professor of the Department of Surgery No. 3;</p><p>40, Pushkinskaya st., Vladikavkaz, 362025.</p></bio><email xlink:type="simple">dina.khubulova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5275-4213</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маскин</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Maskin</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маскин Сергей Сергеевич – д.м.н., профессор, заведующий кафедрой госпитальной хирургии,</p><p>400131, г. Волгоград, площадь Павших Борцов, д. 1.</p></bio><bio xml:lang="en"><p>Maskin Sergey Sergeevich – Doctor of Medical Sciences, Professor, Head of the Department of Hospital Surgery,</p><p>1, Pavshikh Bortsov Sq., Volgograd, 400131.</p></bio><email xlink:type="simple">maskins@bk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Осетинская государственная медицинская академия» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North Ossetian State Medical Academy, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ Республиканская клиническая больница Минздрава РСО-Алания</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican Clinical Hospital of the Ministry of Health of the Republic of North OssetiaAlania</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>12</day><month>09</month><year>2024</year></pub-date><volume>0</volume><issue>3</issue><fpage>196</fpage><lpage>203</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карсанов А.М., Поплавский О.В., Валиев Р.В., Асатрян А.С., Гамаонов Р.С., Хубулова Д.А., Маскин С.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Карсанов А.М., Поплавский О.В., Валиев Р.В., Асатрян А.С., Гамаонов Р.С., Хубулова Д.А., Маскин С.С.</copyright-holder><copyright-holder xml:lang="en">Karsanov A.M., Poplavskiy O.V., Valiev R.V., Asatryan A.S., Gamaonov R.S., Khubulova D.A., Maskin S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mossj.ru/jour/article/view/832">https://www.mossj.ru/jour/article/view/832</self-uri><abstract><sec><title>Введение</title><p>Введение. На современном этапе проблема оказания специализированной неотложной хирургической помощи пациентам старших возрастных групп представляет из себя одну из актуальных клинических задач.</p></sec><sec><title>Результаты</title><p>Результаты. В обзоре с различных позиций анализируется широкое многообразие факторов негативного прогноза при остром аппендиците (ОА) у пожилой когорты пациентов. Эпидемиологические закономерности распространения ОА у лиц пожилого и старческого возраста существенно отличаются от более молодой популяции населения. Даже сели не брать во внимание неоспоримый фактор мультиморбидности, среди пожилых пациентов констатирована более поздняя госпитализация, широкое разнообразие альтернативных ургентных диагнозов, большая частота осложнений ОА и его лечения и, как закономерный итог, большая госпитальная смертность, чем среди молодых пациентов. В ряду причин подобных закономерностей стоят: широкая встречаемость атипичного течения воспаления червеобразного отростка, худшая общая точность современных методов клинико-лабораторных диагностики и большая длительность постановки предоперационного диагноза. В мировой и российской национальной парадигме лечения ОА есть ключевое противоречие в отношении к неоперативному лечению ОА и в своей наиболее острой форме оно проявляется именно на примере пациентов пожилого возраста, частота выполнения аппендэктомии которым в западных странах ниже, чем молодым пациентам.</p></sec><sec><title>Выводы</title><p>Выводы. Диагностика и лечение ОА у лиц старшего возраста представляет из себя гораздо более сложный и технологически более совершенный процесс, чем у больных более молодого возраста, что обусловливает необходимость концентрации повышенного внимания хирургов к данному контингенту пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. At the present stage, the problem of providing specialized emergency surgical care to patients of older age groups is one of the urgent clinical tasks.</p></sec><sec><title>Results</title><p>Results. The review analyzes from various positions a wide variety of factors of negative prognosis in acute appendicitis (AA) in an elderly cohort of patients. Epidemiological patterns of AA prevalence in elderly and senile individuals differ significantly from those in the younger population. Even without taking into account the undeniable factor of multimorbidity, older patients are characterized by later hospitalization, a wide variety of alternative urgent diagnoses, a higher frequency of AA complications and its treatment and, as a natural result, higher hospital mortality than among younger patients. Among the reasons for such patterns are: a wide incidence of atypical course of appendicitis, worse overall accuracy of modern clinical and laboratory diagnostic methods and a longer duration of preoperative diagnosis. In the global and Russian national paradigm of AA treatment, there is a key contradiction in the attitude towards non-surgical treatment of AA, and in its most acute form it is manifested in the example of elderly patients, for whom the frequency of appendectomy in Western countries is lower than for younger patients.</p></sec><sec><title>Conclusions</title><p>Conclusions. Diagnosis and treatment of AA in older people is a much more complex and technologically advanced process than in younger patients, which necessitates the need for surgeons to focus increased attention on this contingent of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хирургия</kwd><kwd>острый аппендицит</kwd><kwd>аппендэктомия</kwd><kwd>пожилые пациенты</kwd><kwd>осложнения лечения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>surgery</kwd><kwd>acute appendicitis</kwd><kwd>appendectomy</kwd><kwd>elderly patients</kwd><kwd>complications of treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fugazzola P., Ceresoli M., Agnoletti V. at al. The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition). World J Emerg Surg, 2020, № 15(1), pp.. 19. doi: 10.1186/s13017-020-00298-0</mixed-citation><mixed-citation xml:lang="en">Fugazzola P., Ceresoli M., Agnoletti V. at al. The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition). World J Emerg Surg, 2020, № 15(1), pp.. 19. doi: 10.1186/s13017-020-00298-0</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gal M., Maya P., Ofer K. at al. Acute Appendicitis in the Elderly: A Nationwide Retrospective Analysis. J Clin Med, 2024, № 13(7), pp. 2139. doi: 10.3390/jcm13072139</mixed-citation><mixed-citation xml:lang="en">Gal M., Maya P., Ofer K. at al. Acute Appendicitis in the Elderly: A Nationwide Retrospective Analysis. J Clin Med, 2024, № 13(7), pp. 2139. doi: 10.3390/jcm13072139</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dhillon N.K., Barmparas G., Lin, T.L. et al. Unexpected complicated appendicitis in the elderly diagnosed with acute appendicitis. Am J Surg, 2019, № 218(6), pp. 1219–1222. doi: 10.1016/j.amjsurg.2019.08.013</mixed-citation><mixed-citation xml:lang="en">Dhillon N.K., Barmparas G., Lin, T.L. et al. Unexpected complicated appendicitis in the elderly diagnosed with acute appendicitis. Am J Surg, 2019, № 218(6), pp. 1219–1222. doi: 10.1016/j.amjsurg.2019.08.013</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Weinandt M., Godiris-Petit G., Menegaux F. at al. Appendicitis is a Severe Disease in Elderly Patients: A Twenty-Year Audit. JSLS, 2020, № 24(3), рр. e2020.00046. doi: 10.4293/JSLS.2020.00046.</mixed-citation><mixed-citation xml:lang="en">Weinandt M., Godiris-Petit G., Menegaux F. at al. Appendicitis is a Severe Disease in Elderly Patients: A Twenty-Year Audit. JSLS, 2020, № 24(3), рр. e2020.00046. doi: 10.4293/JSLS.2020.00046.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ceresoli M., Zucchi A., Allievi N. et al. Acute appendicitis: Epidemiology, treatment and outcomes-analysis of 16544 consecutive cases. World J Gastrointest Surg, 2016, № 8(10), pp. 693–699. doi: 10.4240/wjgs.v8.i10.693</mixed-citation><mixed-citation xml:lang="en">Ceresoli M., Zucchi A., Allievi N. et al. Acute appendicitis: Epidemiology, treatment and outcomes-analysis of 16544 consecutive cases. World J Gastrointest Surg, 2016, № 8(10), pp. 693–699. doi: 10.4240/wjgs.v8.i10.693</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Di Saverio S., Podda M., De Simone B. et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg, 2020, № 15(1), рр. 27. doi: 10.1186/s13017-020-00306-3</mixed-citation><mixed-citation xml:lang="en">Di Saverio S., Podda M., De Simone B. et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg, 2020, № 15(1), рр. 27. doi: 10.1186/s13017-020-00306-3</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jalava K., Sallinen V., Lampela H. et al. Role of preoperative inhospital delay on appendiceal perforation while awaiting appendicectomy (PERFECT): A Nordic, pragmatic, open-label, multicentre, non-inferiority, randomised controlled trial Lancet, 2023, № 402(10412), pp. 1552–1561. doi: 10.1016/S0140-6736(23)01311-9.</mixed-citation><mixed-citation xml:lang="en">Jalava K., Sallinen V., Lampela H. et al. Role of preoperative inhospital delay on appendiceal perforation while awaiting appendicectomy (PERFECT): A Nordic, pragmatic, open-label, multicentre, non-inferiority, randomised controlled trial Lancet, 2023, № 402(10412), pp. 1552–1561. doi: 10.1016/S0140-6736(23)01311-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Körner H., Söndenaa K., Söreide J.A. et al. Incidence of acute nonperforated and perforated appendicitis: age-specific and sex-specific analysis. World J Surg, 1997, № 21(3), pp. 313–317. doi: 10.1007/s002689900235</mixed-citation><mixed-citation xml:lang="en">Körner H., Söndenaa K., Söreide J.A. et al. Incidence of acute nonperforated and perforated appendicitis: age-specific and sex-specific analysis. World J Surg, 1997, № 21(3), pp. 313–317. doi: 10.1007/s002689900235</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mc Gowan D.R., Howlader M.H., Patel R. et al. Management and outcome of appendicitis among octogenarians in an English hospital over a five year period. Int J Surg, 2011, № 9(8), pp. 669–671. doi: 10.1016/j.ijsu.2011.10.004</mixed-citation><mixed-citation xml:lang="en">Mc Gowan D.R., Howlader M.H., Patel R. et al. Management and outcome of appendicitis among octogenarians in an English hospital over a five year period. Int J Surg, 2011, № 9(8), pp. 669–671. doi: 10.1016/j.ijsu.2011.10.004</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ohle R., O’Reilly F., O’Brien K.K. et al. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med, 2011, № 9, e39. doi: 10.1186/1741-7015-9-139</mixed-citation><mixed-citation xml:lang="en">Ohle R., O’Reilly F., O’Brien K.K. et al. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med, 2011, № 9, e39. doi: 10.1186/1741-7015-9-139</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta S., Kolli V.S., Da Costa K. et al. A systematic review and meta-regression for validation of the Alvarado score as a tool for predicting acute appendicitis. Ann Med Surg (Lond), 2023, № 85(2), pp. 111–121. doi: 10.1097/MS9.0000000000000238</mixed-citation><mixed-citation xml:lang="en">Gupta S., Kolli V.S., Da Costa K. et al. A systematic review and meta-regression for validation of the Alvarado score as a tool for predicting acute appendicitis. Ann Med Surg (Lond), 2023, № 85(2), pp. 111–121. doi: 10.1097/MS9.0000000000000238</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mehbub H., Baig A.A., Khalid R. et al. A Comparison of the Modified Alvarado Score and the Raja Isteri Pengiran Anak Saleha Appendicitis (Ripasa) Score in a Southeast Asian Population with Histopathology as the Gold Standard. Cureus, 2023, № 15(10), e46715. doi: 10.7759/cureus.46715</mixed-citation><mixed-citation xml:lang="en">Mehbub H., Baig A.A., Khalid R. et al. A Comparison of the Modified Alvarado Score and the Raja Isteri Pengiran Anak Saleha Appendicitis (Ripasa) Score in a Southeast Asian Population with Histopathology as the Gold Standard. Cureus, 2023, № 15(10), e46715. doi: 10.7759/cureus.46715</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Echevarria S., Rauf F., Hussain N. et al. Typical and Atypical Presentations of Appendicitis and Their Implications for Diagnosis and Treatment: A Literature Review. Cureus. 2023, № 15(4), рр. e37024. doi: 10.7759/cureus.37024</mixed-citation><mixed-citation xml:lang="en">Echevarria S., Rauf F., Hussain N. et al. Typical and Atypical Presentations of Appendicitis and Their Implications for Diagnosis and Treatment: A Literature Review. Cureus. 2023, № 15(4), рр. e37024. doi: 10.7759/cureus.37024</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tian B. W.C.A., Agnoletti V., Ansaloni L. et al. Management of Intra-Abdominal Infections: The Role of Procalcitonin. Antibiotics (Basel), 2023, № 12(9), рр. e1406. doi: 10.3390/antibiotics12091406</mixed-citation><mixed-citation xml:lang="en">Tian B. W.C.A., Agnoletti V., Ansaloni L. et al. Management of Intra-Abdominal Infections: The Role of Procalcitonin. Antibiotics (Basel), 2023, № 12(9), рр. e1406. doi: 10.3390/antibiotics12091406</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Teng T.Z.J., Thong X.R., Lau K.Y. et al. Acute appendicitis-advances and controversies. World J Gastrointest Surg, 2021, № 13(11), pp. 1293–1314. doi: 10.4240/wjgs.v13.i11.1293</mixed-citation><mixed-citation xml:lang="en">Teng T.Z.J., Thong X.R., Lau K.Y. et al. Acute appendicitis-advances and controversies. World J Gastrointest Surg, 2021, № 13(11), pp. 1293–1314. doi: 10.4240/wjgs.v13.i11.1293</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kraemer M., Franke C., Ohmann C., Yang Q. Acute Abdominal Pain Study. Acute appendicitis in late adulthood: incidence, presentation, and outcome. Results of a prospective multicenter acute abdominal pain study and a review of the literature. Langenbecks Arch. Surg, 2000, № 385(7), pp. 470–481. doi: 10.1007/s004230000165.</mixed-citation><mixed-citation xml:lang="en">Kraemer M., Franke C., Ohmann C., Yang Q. Acute Abdominal Pain Study. Acute appendicitis in late adulthood: incidence, presentation, and outcome. Results of a prospective multicenter acute abdominal pain study and a review of the literature. Langenbecks Arch. Surg, 2000, № 385(7), pp. 470–481. doi: 10.1007/s004230000165.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Solis-Pazmino P., Oka K., La K. et al. Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review. Langenbecks Arch Surg, 2023, № 408(1), e432. doi: 10.1007/s00423-023-03164-0</mixed-citation><mixed-citation xml:lang="en">Solis-Pazmino P., Oka K., La K. et al. Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review. Langenbecks Arch Surg, 2023, № 408(1), e432. doi: 10.1007/s00423-023-03164-0</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller T., Dimpel R., Kehl V. et al. Surgical site infection prevention in abdominal surgery: is intraoperative wound irrigation with antiseptics effective? Protocol for a systematic review and meta-analysis. BMJ Open, 2023, № 13(2), рр. e066140. doi: 10.1136/bmjopen-2022-066140</mixed-citation><mixed-citation xml:lang="en">Mueller T., Dimpel R., Kehl V. et al. Surgical site infection prevention in abdominal surgery: is intraoperative wound irrigation with antiseptics effective? Protocol for a systematic review and meta-analysis. BMJ Open, 2023, № 13(2), рр. e066140. doi: 10.1136/bmjopen-2022-066140</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Renteria O., Shahid Z., Huerta S. Outcomes of appendectomy in elderly veteran patients. Surgery, 2018, № 164(3), pp. 460–465. doi: 10.1016/j.surg.2018.04.027</mixed-citation><mixed-citation xml:lang="en">Renteria O., Shahid Z., Huerta S. Outcomes of appendectomy in elderly veteran patients. Surgery, 2018, № 164(3), pp. 460–465. doi: 10.1016/j.surg.2018.04.027</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Peltrini R., Cantoni V., Green R. et al. Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis. Surgeon. 2021, № 19(6), рр. e549–e558. doi: 10.1016/j.surge.2021.01.010</mixed-citation><mixed-citation xml:lang="en">Peltrini R., Cantoni V., Green R. et al. Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis. Surgeon. 2021, № 19(6), рр. e549–e558. doi: 10.1016/j.surge.2021.01.010</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Cong S., Wu G., Jin Y., Zhu L. Efficacy and Adverse Reactions of Dahuang Mudan decoction Combined with Laparoscopy in the Treatment of Appendicitis: A Meta-Analysis. Altern Ther Health Med, 2023, № 29(8), pp. 822–829.</mixed-citation><mixed-citation xml:lang="en">Cong S., Wu G., Jin Y., Zhu L. Efficacy and Adverse Reactions of Dahuang Mudan decoction Combined with Laparoscopy in the Treatment of Appendicitis: A Meta-Analysis. Altern Ther Health Med, 2023, № 29(8), pp. 822–829.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fung S., Yu Z. Meta-analysis of the clinical effect of traditional Chinese medicine and antibiotics in the treatment of acute appendicitis. J Gastroenterol Res Pract, 2023, № 3(10), рр. e1173.</mixed-citation><mixed-citation xml:lang="en">Fung S., Yu Z. Meta-analysis of the clinical effect of traditional Chinese medicine and antibiotics in the treatment of acute appendicitis. J Gastroenterol Res Pract, 2023, № 3(10), рр. e1173.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Teixeira F.J.R. Jr., Couto Netto S.D.D., Akaishi E.H. et al. Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature. World J Emerg Surg, 2017, № 12, рр. e12. doi: 10.1186/s13017-017-0122-9</mixed-citation><mixed-citation xml:lang="en">Teixeira F.J.R. Jr., Couto Netto S.D.D., Akaishi E.H. et al. Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature. World J Emerg Surg, 2017, № 12, рр. e12. doi: 10.1186/s13017-017-0122-9</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Alajääski J., Lietzén E., Grönroos J.M. et al. The association between appendicitis severity and patient age with appendiceal neoplasm histology-a population-based study. Int J Colorectal Dis, 2022, № 37(5), pp. 1173–1180. doi: 10.1007/s00384-022-04132-8</mixed-citation><mixed-citation xml:lang="en">Alajääski J., Lietzén E., Grönroos J.M. et al. The association between appendicitis severity and patient age with appendiceal neoplasm histology-a population-based study. Int J Colorectal Dis, 2022, № 37(5), pp. 1173–1180. doi: 10.1007/s00384-022-04132-8</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
