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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mossj</journal-id><journal-title-group><journal-title xml:lang="ru">Московский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Moscow Surgical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-3180</issn><publisher><publisher-name>ООО «ПРОФИЛЬ – 2С»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/2072-3180-2024-3-40-49</article-id><article-id custom-type="elpub" pub-id-type="custom">mossj-814</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АБДОМИНАЛЬНАЯ ХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABDOMINAL SURGERY</subject></subj-group></article-categories><title-group><article-title>Опыт регионального центра в лечении острого аппендицита у детей</article-title><trans-title-group xml:lang="en"><trans-title>Experience of a regional Center in Treating Acute Appendicitis in Children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8590-2350</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тонеев</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Toneev</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тонеев Евгений Александрович – кандидат медицинских наук, врач - торакальный хирург хирургического отделения торакальной онкологии; доцент кафедры факультетской хирургии, мед. факультета им. Т.З. Биктимирова Института медицины, экологии и физической культуры</p><p> 432017, Ульяновск, ул. 12-сентября, д. 90;</p><p>432011, Ульяновск, ул. Л. Толстого, д. 42.</p></bio><bio xml:lang="en"><p>Toneev Evgeny Aleksandrovich – Candidate of Medical Sciences, Thoracic Surgeon of the Surgical Department of Thoracic Oncology; Associate Professor of the Faculty Surgery Department, T.Z. Biktimirov Medical Faculty, Institute of Medicine, Ecology, and Physical Education,</p><p>90, 12th of September St., Ulyanovsk, 432017;</p><p>42, L. Tolstoy St., Ulyanovsk, 432011.</p></bio><email xlink:type="simple">e.toneev@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-6993-2463</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пайзе</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Paize</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пайзе Ольга Николаевна – врач - детский хирург хирургического отделения,</p><p>432011, Ульяновск, ул. Радищева, д. 42.</p></bio><bio xml:lang="en"><p>Paize Olga Nikolaevna – Doctor, Pediatric Surgeon, Surgical Department,</p><p>42, Radishcheva St., Ulyanovsk, 432011.</p></bio><email xlink:type="simple">Helga@blamange.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-0218-666X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шагдалеев</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Shagdaleev</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шагдалеев Роман Фатыхович – ординатор кафедры госпитальной хирургии, анестезиологии, реаниматологии, урологии, травматологии и ортопедии, факультет стоматологии, фармации и последипломного медицинского образования, Институт медицины, экологии и физической культуры,</p><p>432011, Ульяновск, ул. Л. Толстого, д. 42.</p></bio><bio xml:lang="en"><p>Shagdaleev Roman Fatykhovich – Resident of the Department of Hospital Surgery, Anesthesiology, Resuscitation, Urology, Traumatology, and Orthopedics, Faculty of Dentistry, Pharmacy, and Postgraduate Medical Education, Institute of Medicine, Ecology, and Physical Education,</p><p>42, L. Tolstoy St., Ulyanovsk, 432011.</p></bio><email xlink:type="simple">roman2000shagdaleev@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0827-0115</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прохоров</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokhorov</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Прохоров Даниил Дмитриевич – ординатор кафедры госпитальной хирургии, анестезиологии, реаниматологии, урологии, травматологии и ортопедии, факультет стоматологии, фармации и последипломного медицинского образования, Институт медицины, экологии и физической культуры,</p><p>432011, Россия, Ульяновск, ул. Л. Толстого, д. 42.</p></bio><bio xml:lang="en"><p>Prokhorov Daniil Dmitrievich – resident of the Department of Hospital Surgery, Anesthesiology, Resuscitation, Urology, Traumatology, and Orthopedics, Faculty of Dentistry, Pharmacy, and Postgraduate Medical Education, Institute of Medicine, Ecology, and Physical Education,</p><p>42, L. Tolstoy St., Ulyanovsk, 432011.</p></bio><email xlink:type="simple">prokhrow143@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1067-0048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бехтина</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bekhtina</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бехтина Олеся Юрьевна – врач - детский хирург хирургического отделения</p><p>432011, Ульяновск, ул. Радищева, д. 42.</p></bio><bio xml:lang="en"><p>Bekhtina Olesya Yurievna – Doctor, Pediatric Surgeon, Surgical Department,</p><p>42, Radishcheva St., Ulyanovsk, 432011.</p></bio><email xlink:type="simple">behtina24@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУЗ Областной клинический онкологический диспансер; ФГБОУ ВО Ульяновский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Clinical Oncology Dispensary of Ulyanovsk; Ulyanovsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГУЗ Ульяновская областная детская клиническая больница им. Ю.Ф. Горячева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ulyanovsk Regional Children’s Clinical Hospital named after Y.F. Goryachev</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Ульяновский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ulyanovsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>09</month><year>2024</year></pub-date><volume>0</volume><issue>3</issue><fpage>40</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тонеев Е.А., Пайзе О.Н., Шагдалеев Р.Ф., Прохоров Д.Д., Бехтина О.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Тонеев Е.А., Пайзе О.Н., Шагдалеев Р.Ф., Прохоров Д.Д., Бехтина О.Ю.</copyright-holder><copyright-holder xml:lang="en">Toneev E.A., Paize O.N., Shagdaleev R.F., Prokhorov D.D., Bekhtina O.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mossj.ru/jour/article/view/814">https://www.mossj.ru/jour/article/view/814</self-uri><abstract><sec><title>10</title><p>10.17238/2072-3180-2024-3-40-49</p></sec><sec><title> </title><p> </p></sec><sec><title>Введение</title><p>Введение. Цель данного исследования заключается в оценке эффективности лабораторных индексов воспалительного ответа при прогнозировании развития острого аппендицита у детей. Материалы и методы. Ретроспективно проанализированы данные 300 пациентов детского возраста, которым выполнена аппендэктомия по поводу острого аппендицита, на базе хирургического отделения ГУЗ «Ульяновская областная детская клиническая больница» г. Ульяновск в период с 01.09.2023 г. по 01.06.2024 г.</p></sec><sec><title>Полученные результаты</title><p>Полученные результаты. При анализе результатов, было выявлено, что статистически значимо чаще встречается флегмонозный аппендицит (145), в возрасте 6–12 лет (p=0,048). При однофакторном статистическом анализе получено, что статистически значимыми параметрами в зависимости от типа острого аппендицита, являются рвота (p=0,001) и временной интервал от начала заболевания (появление первых симптомов) до выполнения хирургического вмешательства (p&lt;0,001). При однофакторном статистическом анализе инструментально-лабораторных параметров получены следующие статистически-значимые индикаторы развития ОА: УЗИ-признаки воспалительного процесса червеобразного отростка (p&lt;0,001), индекс Гаркави (p&lt;0,001),  ЛИИ (p&lt;0,001) НЛИ (p&lt;0,001) и ТЛИ (p&lt;0,001).</p></sec><sec><title>Выводы</title><p>Выводы. Среди пациентов детского возраста острый аппендицит наиболее часто встречается в возрасте 6–12 лет, и представлен преимущественно флегмонозной формой. Значимыми индикаторами, позволяющими определить развитие острого аппендицита и характер его течения, являются: НЛИ, ТЛИ, ЛИИ, индекс Гаркави и результаты ультразвукового исследования червеобразного отростка. Комплексное применение данных индикаторов в диагностике острого позволяет своевременно дифференцировать ОА.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The aim of this study is to evaluate the effectiveness of laboratory indices of inflammatory response in predicting the development of acute appendicitis in children.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Data on 300 pediatric patients who underwent appendectomy for acute appendicitis at the surgical department of the State Healthcare Institution "Ulyanovsk Regional Children's Clinical Hospital" in Ulyanovsk were retrospectively analyzed for the period from September 1, 2023, to June 1, 2024.</p></sec><sec><title>Results</title><p>Results. Upon analyzing the results, it was revealed that phlegmonous appendicitis (145 cases) occurs statistically significantly more often in the age group of 6–12 years (𝑝=0,048). Univariate statistical analysis showed that the statistically significant parameters depending on the type of acute appendicitis are vomiting (𝑝 &lt;0,001) and the time interval from the onset of the disease (appearance of the first symptoms) to the performance of surgical intervention (𝑝&lt;0,001). Univariate statistical analysis of instrumental-laboratory parameters yielded the following statistically significant indicators of acute appendicitis development: Ultrasound signs of inflammation of the vermiform appendix (𝑝&lt;0,001), Garkavi index (𝑝&lt;0,001), LII (Leukocyte intoxication index) (𝑝&lt;0,001), NLI (Neutrophil-lymphocyte index) (𝑝&lt;0,001), and TLI (Thrombocyte-lymphocyte index) (𝑝&lt;0,001).</p></sec><sec><title>Conclusion</title><p>Conclusion. Among pediatric patients, acute appendicitis most commonly occurs in the age group of 6–12 years and is diagnosed as phlegmonous appendicitis. Significant indicators that allow determining the development of acute appendicitis and the nature of its course include: NLI, TLI, LII, Garkavi index, and the results of ultrasound examination of the vermiform appendix. The comprehensive use of these indicators in the diagnosis of acute appendicitis will allow for the timely diagnosis of the condition.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый аппендицит у детей</kwd><kwd>аппендэктомия у детей</kwd><kwd>деструктивный аппендицит</kwd><kwd>прогнозирование острого аппендицита</kwd><kwd>индикаторы острого аппендицита</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute appendicitis in children</kwd><kwd>appendectomy</kwd><kwd>destructive appendicitis</kwd><kwd>prognosis of acute appendicitis</kwd><kwd>indicators of acute appendicitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хирургическая помощь в Российской Федерации. Информационно-аналитический сборник за 2022 год. https://anyflip.com/nvzse/vipw/ (Дата обращения: 23.05.2024)</mixed-citation><mixed-citation xml:lang="en">Surgical care in the Russian Federation. 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