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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mossj</journal-id><journal-title-group><journal-title xml:lang="ru">Московский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Moscow Surgical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-3180</issn><publisher><publisher-name>ООО «ПРОФИЛЬ – 2С»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/2072-3180-2023-19-28</article-id><article-id custom-type="elpub" pub-id-type="custom">mossj-709</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Проблема развития желчнокаменной болезни у пациентов, перенесших бариатрическую операцию</article-title><trans-title-group xml:lang="en"><trans-title>The problem of gallstone disease development in patients undergoing bariatric surgery</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4925-0126</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Неймарк</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Neimark</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Неймарк Александр Евгеньевич – кандидат медицинскихнаук, доцент, руководитель лаборатории НИЛ хирургии метаболических нарушений, ведущий научный сотрудник, врач-хирург; врач-хирург, гастроэнтерологический центр «Эксперт»</p><p>197341, ул. Аккуратова д.2, Санкт-Петербург</p><p>197110, ул. Пионерская, д. 16, Санкт- Петербург</p></bio><bio xml:lang="en"><p>Neimark Aleksandr Evgenyevich – Candidate of Medical Sciences, Associate Professor, Head of the Laboratory of the Research Laboratory for Surgery of Metabolic Disorders, Leading Researcher, Surgeon; surgeon, gastroenterological center «Expert»</p><p>197341, st. Akkuratova 2, St. Petersburg</p><p>197110, st. Pionerskaya, 16, St. Petersburg</p></bio><email xlink:type="simple">sas_spb@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7367-9219</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мехтиев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mekhtiev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мехтиев Сабир Насрединович – доктор медицинских наук, профессор кафедры терапии госпитальной с курсом аллергологии и иммунологии имени академика М.В. Черноруцкого с клиникой, Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; председатель гепатосекции Санкт-Петербургского общества терапевтов имени С.П. Боткина; главный врач, гастроэнтерологический центр «Эксперт»</p><p>197110, ул. Пионерская, д. 16, Санкт- Петербург</p></bio><bio xml:lang="en"><p>Mekhtiev Sabir Nasredinovich – Doctor of Medical Sciences, Professor of the Department of Hospital Therapy with a Course of Allergology and Immunology named after Academician M.V. Chernorutsky with the clinic, First St. Petersburg State Medical University named after Academician I.P. Pavlova; Chairman of the Hepatosection of the St. Petersburg Society of Therapists named after S.P. Botkin; chief physician, gastroenterological center «Expert»</p><p>197022, st. Leo Tolstoy, 6–8, St. Petersburg</p><p>197110, st. Pionerskaya, 16, St. Petersburg</p></bio><email xlink:type="simple">sabirm@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3454-4690</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корнюшин</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kornyushin</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корнюшин Олег Викторович – кандидат медицинских наук, ведущий научный сотрудник НИЛ хирургической коррекции метаболических нарушений, старший научный сотрудник НИЛ метаболизма миокарда, врач-хирург </p><p>197341, ул. Аккуратова, д.2, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Kornyushin Oleg Viktorovich – Candidate of Medical Sciences, Leading Researcher at the Research Laboratory for Surgical Correction of Metabolic Disorders, Senior Researcher at the Research Laboratory of Myocardial Metabolism, Surgeon </p><p>197341, st. Akkuratova 2, St. Petersburg</p></bio><email xlink:type="simple">o.kornyushin@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7379-6896</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Берко</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Berko</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Берко Олеся Михайловна – врач-гастроэнтеролог</p><p>194291, пр. Культуры, д. 4, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Berko Olesya Mikhailovna – gastroenterologist</p><p>194291, Avenue of Culture 4, St. Petersburg</p></bio><email xlink:type="simple">berkoolesya@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России; ФГБУ СЗОНКЦ им. Л.Г. Соколова ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>«Almazov National Medical Research Centre» of the Ministry of Health of the Russian Federation; The Federal State Budgetary Institution "North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ СЗОНКЦ им. Л.Г. Соколова ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Federal State Budgetary Institution "North-Western district scientific and clinical center named after L. G. Sokolov Federal Medical and Biological Agency"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>«Almazov National Medical Research Centre» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2023</year></pub-date><volume>0</volume><issue>0</issue><issue-title>Сентябрь. Спецвыпуск</issue-title><fpage>19</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Неймарк А.Е., Мехтиев С.Н., Корнюшин О.В., Берко О.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Неймарк А.Е., Мехтиев С.Н., Корнюшин О.В., Берко О.М.</copyright-holder><copyright-holder xml:lang="en">Neimark A.E., Mekhtiev S.N., Kornyushin O.V., Berko O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mossj.ru/jour/article/view/709">https://www.mossj.ru/jour/article/view/709</self-uri><abstract><sec><title>Введение</title><p>Введение. Бариатрическая хирургия признана высокоэффективным и безопасным методом лечения ожирения и коморбидных состояний, однако послеоперационный период сопряжен с риском возникновения ряда осложнений. К их числу относится желчнокаменная болезнь (ЖКБ), ассоциированная с быстрой потерей веса вследствие выполненного хирургического вмешательства. В настоящее время не существует стандартизированных схем профилактики ЖКБ у бариатрических пациентов, а порой сама необходимость ее проведения остается предметом дискуссий. </p></sec><sec><title>Цель</title><p>Цель. Представить литературный обзор, посвященный эпидемиологии ЖКБ и мерам ее профилактики после различных видов бариатрических вмешательств. </p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен поиск отечественных и зарубежных литературных источников, соответствующих заданной цели, на доступных интернет-ресурсах с последующим анализом: более 50 публикаций, 27 из них цитированы в данной статье.</p></sec><sec><title>Результаты</title><p>Результаты. Частота развития ЖКБ после бариатрических операций составляет от 6,5 до 38 % (в среднем около 25 %), симптоматической ЖКБ – от 3,3 до 17,5 %, потребность в проведении холецистэктомии – от 6,2 до 14,7 %. Назначение УДХК в дозе 500–600 мг в сутки в течение 6 и более месяцев является эффективной мерой профилактики развития ЖКБ после всех видов баритарических операций. Профилактическая холецистэктомия преимущественно выполняется пациентам с симптоматической ЖКБ на дооперационном этапе.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Bariatric surgery is recognized as a highly effective and safe treatment for obesity and comorbid conditions. Nevertheless the postoperative period is associated with the risk of a number of complications, including gallstone disease (GSD). The reason of GSD is rapid weight loss due to surgical intervention. Currently, there are no standardized schemes for the prevention of cholelithiasis in bariatric patients. Moreover, sometimes implementation of this prevention remains the subject of discussion.</p></sec><sec><title>Aim</title><p>Aim. To present a literature review on the epidemiology of GBD and measures for its prevention after various types of bariatric interventions.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The analysis of domestic and foreign literary sources appropriate for a given purpose on available Internet resources was carried out. More than 50 scientific publications were studied, 27 of them are listed in this article.</p></sec><sec><title>Results</title><p>Results. The incidence of GSD after bariatric surgery ranges from 6,5 to 38 % (about 25 % on average), symptomatic cholelithiasis – from 3,3 to 17,5 %, the need for cholecystectomy – from 6,2 to 14,7 %. The appointment of UDCA at a dose of 500–600 mg per day for 6 or more months is an effective measure to prevent the development of cholelithiasis after all types of baritary operations. Prophylactic cholecystectomy is predominantly performed in patients with symptomatic cholelithiasis at the preoperative stage.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>бариатрическая хирургия</kwd><kwd>ЖКБ</kwd><kwd>профилактика</kwd><kwd>УДХК</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bariatric surgery</kwd><kwd>GSD</kwd><kwd>prevention</kwd><kwd>UDCA</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Di Ciaula A., Wang D.Q., Portincasa P. 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