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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mossj</journal-id><journal-title-group><journal-title xml:lang="ru">Московский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Moscow Surgical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-3180</issn><publisher><publisher-name>ООО «ПРОФИЛЬ – 2С»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/2072-3180-2025-3-102-110</article-id><article-id custom-type="elpub" pub-id-type="custom">mossj-1028</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНКОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>Результаты лечения пациентов с гепатоцеллюлярной карциномой</article-title><trans-title-group xml:lang="en"><trans-title>The treatment results of patients with hepatocellular carcinoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-2147-5929</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вахромкин</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vakhromkin</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вахромкин Владимир Сергеевич – ассистент кафедры оперативной хирургии и топографической анатомии; врач-хирург 2-го хирургического отделения Университетской клиники НОИ клинической медицины им. Н.А. Семашко</p><p>111398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Vakhromkin Vladimir Sergeevich – the assistant of the Department of Operative Surgery and Topographic Anatomy, the surgeon of the 2nd Surgical Department of the University Clinic of the N.A. Semashko</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">vladimir@vakhromkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0190-5285</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трандофилов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Trandofilov</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трандофилов Михаил Михайлович – д.м.н., профессор кафедры оперативной хирургии и топографической анатомии, врач-хирург хирургического отделения Университетской клиники НОИ клинической медицины им. Н.А. Семашко</p><p>11398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Trandofilov Mikhail Mikhailovich – PhD in medicine, the professor of the Department of Operative Surgery and Topographic Anatomy, the surgeon of the Surgical Department of the University Clinic of the N.A. Semashko</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">mikhailtrandofilov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Праздников</surname><given-names>Э. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Prazdnikov</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Праздников Эрик Нариманович – д.м.н., профессор, заведующий кафедрой оперативной хирургии и топографической анатомии</p><p>11398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Prazdnikov Eric Narimanovich – PhD in medicine, professor, the head of the Department of Operative Surgery and Topographic Anatomy</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">enp1964@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1751-4601</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Радмила Владимировна – д.м.н., профессор, главный специалист отдела медицинских наук РАН, профессор, кафедра факультетской хирургии ИХ</p><p>119991, г. Москва, Ленинский проспект, 14. 117513, г. Москва, ул. Островитянова, 1/6</p></bio><bio xml:lang="en"><p>Karpova Radmila Vladimirovna – PhD in medicine, Chief Specialist of the Department of Medical Sciences of the Russian Academy of Sciences, Professor, Department of Faculty Surgery</p><p>119991, Moscow, Leninsky Prospekt, 14. 117513, Moscow, st. Ostrovityanova, 1/6</p></bio><email xlink:type="simple">radmila.71@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-5785-2100</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доспехов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dospekhov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доспехов Даниил Валентинович – ассистент кафедры оперативной хирургии и топографической анатомии</p><p>111398, Москва, ул. Кусковская, 1А, стр. 4</p></bio><bio xml:lang="en"><p>Dospekhov Daniil Valentinovich – the assistant of the Department of Operative Surgery and Topographic Anatomy</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">d-dospehov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8667-9960</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плеханова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Plekhanova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плеханова Елена Николаевна – ассистент кафедры патологической анатомии</p><p>11398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Plekhanova Elena Nikolaevna – the assistant of the Department of Pathological Anatomy</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7092-3674</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошелев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Koshelev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кошелев Игорь Андреевич – ассистент кафедры оперативной хирургии и топографической анатомии, заведующий 2 хирургическим отделением Университетской клиники НОИ клинической медицины им. Н.А. Семашко</p><p>11398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Koshelev Igor Andreevich – the assistant of the Department of Operative Surgery and Topographic Anatomy, the head of the 2nd Surgical Department of the University Clinic of the N.A.</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">koshelev933504@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-3199-0621</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Резниченко</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reznichenko</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Резниченко Виталий Владимирович – ассистент кафедры оперативной хирургии и топографической анатомии</p><p>11398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Reznichenko Vitaly Vladimirovich – the assistant of the Department of Operative Surgery and Topographic Anatomy</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">vitalij.rezni4enko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-9449-5717</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагимов</surname><given-names>Ф. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragimov</surname><given-names>F. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рагимов Фарид Эмин оглы – аспирант кафедры оперативной хирургии и топографической анатомии</p><p>11398, Москва, ул. Кусковская, 1А, стр. 4 </p></bio><bio xml:lang="en"><p>Ragimov Farid Emin ogly – postgraduate student of the Department of Operative Surgery and Topographic Anatomy</p><p>111398, Kuskovskaya 1A str., building 4, Moscow</p></bio><email xlink:type="simple">farid9988@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО “Российский университет медицины” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBEI HE "Russian University of Medicine (RUM)" of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение "Российская академия наук" ; ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Academy of Sciences ; Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>102</fpage><lpage>110</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вахромкин В.С., Трандофилов М.М., Праздников Э.Н., Карпова Р.В., Доспехов Д.В., Плеханова Е.Н., Кошелев И.А., Резниченко В.В., Рагимов Ф.Э., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Вахромкин В.С., Трандофилов М.М., Праздников Э.Н., Карпова Р.В., Доспехов Д.В., Плеханова Е.Н., Кошелев И.А., Резниченко В.В., Рагимов Ф.Э.</copyright-holder><copyright-holder xml:lang="en">Vakhromkin V.S., Trandofilov M.M., Prazdnikov E.N., Karpova R.V., Dospekhov D.V., Plekhanova E.N., Koshelev I.A., Reznichenko V.V., Ragimov F.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mossj.ru/jour/article/view/1028">https://www.mossj.ru/jour/article/view/1028</self-uri><abstract><p>Введение. Гепатоцеллюлярная карцинома (ГЦК) – первичная опухоль, составляющая 80 – 85 % от всех злокачественных образований печени. По данным мировой статистики заболеваемость ГЦК занимает – 6 место, а летальность – 3 место. Распространенность заболевания в РФ выросла на 8 % за последние 5 лет и составляет 4-5 случаев на 100 тыс. населения в год, при этом III–IV стадии занимают около 80 %. Лечение данной патологии представляет собой сложную задачу и должно учитывать многие факторы. Цель исследования заключалась в анализе результатов лечения больных с ГЦК за период с 2008 г. по 2024 г.Материалы и методы исследования. Проведен ретроспективный анализ лечения 197 больных с гепатоцеллюлярной карциномой (ГЦК), средний возраст составил 61,3 ± 8,5 года, мужчин – 140 (71 %), женщин – 57 (29 %). Резекция печени выполнена 82 пациентам, локорегионарные методики – 119 пациентам.Результаты лечения. Cредняя продолжительность времени операции составила 179 ± 28,3 мин; средний койко–день составил 11 ± 3 день; продолжительность жизни составила однолетняя 83 %, двухлетняя 75 %, трехлетняя 50 %, пятилетняя 32 %. При ЛРТ средняя продолжительность воздействия при РЧА составила 12 ± 2,8 мин, при МВА – 7 ± 2,3 мин, при ЛА – 6 мин, продолжительность жизни при выполнении РЧА опухолей печени однолетняя составила 81 %, двухлетняя – 62 %, трехлетняя – 39 %, пятилетняя – 28 %. При выполнении МВА опухолей печени продолжительность жизни однолетняя составила 83 %, двухлетняя – 67 %, трехлетняя – 42 %, пятилетняя – 31 %.Заключение. Комплексный подход к лечению пациентов с первичным раком печени позволяет определить оптимальную тактику, что повышает эффективность лечения, увеличивает продолжительность жизни и повышает ее качество, делает возможным применение локальных методов у соматически отягощенных больных.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Hepatocellular carcinoma (HCC) is a primary tumor, accounting for 80–85 % of all malignant liver tumors. According to world statistics, the incidence of HCC ranks 6th, and mortality – 3rd. The prevalence of the disease in the Russian Federation has increased by 8 % over the past 5 years and is 4–5 cases per 100 thousand population per year, while stages III–IV account for about 80 %. Treatment of this pathology is a complex task and should take into account many factors. The aim of the study was to analyze the treatment results of patients with HCC for the period from 2008 to 2024.Materials and methods of research. A retrospective analysis of the treatment of 197 patients with hepatocellular carcinoma (HCC) was performed, the average age was 61.3 ± 8.5 years, men – 140 (71 %), women – 57 (29 %). Liver resection was performed in 82 patients, locoregional techniques were performed in 119 patients.Treatment results. The average duration of the operation was 179 ± 28,3 min; the average bed-day was 11 ± 3 days; the survival rate was 83 % at one year, 75 % at two years, 50 % at three years, and 32 % at five years. The time of LRT procedures were as follows: RFA –12 ± 2,8 min, MVA – 7 ± 2,3 min, LA – 6 min. The survival rate after RFA of liver tumors was 81% at one year, 62 % at two years, 39 % at three years, and 28 % at five years. When performing MVA of liver tumors, the survival rate was 83 % at one year, 67 % at two years, 42 % at three years, and 31 % at five years.Conclusion. An integrated approach to the treatment of patients with primary liver cancer allows us to determine the optimal tactics, which increases the effectiveness of treatment, increases life expectancy and improves its quality, and makes it possible to use local methods in somatically burdened patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гепатоцеллюлярный рак</kwd><kwd>резекция печени</kwd><kwd>микроволновая абляция</kwd><kwd>радиочастотная абляция</kwd><kwd>лазерная абляция</kwd><kwd>трансартериальная химиоэмболизация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hepatocellular carcinoma</kwd><kwd>liver resection</kwd><kwd>microwave ablation</kwd><kwd>radiofrequency ablation</kwd><kwd>laser ablation</kwd><kwd>transarterial chemoembolization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бредер В. В. и др. 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